Complex I and II are required for normal mitochondrial Ca2+ homeostasis

Fabian Jaña, G. Bustos, José Rivas, P. Cruz, F. Urra, C. Basualto-Alarcón, Eduardo Sagredo, Melany Ríos, Alenka Lovy, Zhiwei Dong, O. Cerda, Muniswamy Madesh, César Cárdenas

Resultado de la investigación: Articlerevisión exhaustiva

16 Citas (Scopus)

Resumen

Cytosolic calcium (cCa2+) entry into mitochondria is facilitated by the mitochondrial membrane potential (ΔΨm), an electrochemical gradient generated by the electron transport chain (ETC). Is has been assumed that as long as mutations that affect the ETC do not affect the ΔΨm, the mitochondrial Ca2+ (mCa2+) homeostasis remains normal. We show that knockdown of NDUFAF3 and SDHB reduce ETC activity altering mCa2+ efflux and influx rates while ΔΨm remains intact. Shifting the equilibrium toward lower [Ca2+]m accumulation renders cells resistant to death. Our findings reveal an unexpected relationship between complex I and II with the mCa2+ homeostasis independent of ΔΨm.

Idioma originalEnglish (US)
Páginas (desde-hasta)73-82
Número de páginas10
PublicaciónMitochondrion
Volumen49
DOI
EstadoPublished - nov. 2019

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Cell Biology

Huella

Profundice en los temas de investigación de 'Complex I and II are required for normal mitochondrial Ca2+ homeostasis'. En conjunto forman una huella única.

Citar esto