Comparison of noncontingent versus contingent cocaine administration on plasma corticosterone levels in rats

Ruggero Galici, Robert N. Pechnick, Russell E. Poland, Charles P. France

Resultado de la investigación: Articlerevisión exhaustiva

62 Citas (Scopus)

Resumen

The purpose of the present study was to compare the effects of contingent and noncontingent cocaine administration on plasma levels of corticosterone in rats. Male rats were trained to self-administer cocaine under a fixed-ratio 5 schedule. The rats were yoked such that the delivery of cocaine (0.25 mg/kg/infusion) to one rat (contingent cocaine) produced the simultaneous noncontingent delivery of the same dose of cocaine (noncontingent cocaine) or saline (noncontingent saline) to other rats. Although saline administration had no effect, plasma corticosterone levels were significantly higher in rat receiving contingent cocaine compared to those receiving noncontingent cocaine. These results demonstrate that the active vs. passive administration of cocaine can differentially affect this neuroendocrine response. Copyright (C) 2000 Elsevier Science B.V.

Idioma originalEnglish (US)
Páginas (desde-hasta)59-62
Número de páginas4
PublicaciónEuropean Journal of Pharmacology
Volumen387
N.º1
DOI
EstadoPublished - nov. 3 2000
Publicado de forma externa

ASJC Scopus subject areas

  • Pharmacology

Huella

Profundice en los temas de investigación de 'Comparison of noncontingent versus contingent cocaine administration on plasma corticosterone levels in rats'. En conjunto forman una huella única.

Citar esto