TY - JOUR
T1 - Comparative structural analysis of human and rat 65 kDa tumor-associated phosphoproteins
AU - Mirowski, Marek
AU - Walaszek, Zbigniew
AU - Sherman, Ute
AU - Hanausek, Malgorzata
N1 - Funding Information:
Acknowledgements-We thank Dr W. Karshin and Ron Shonk of The University of Texas, M.D. Anderson Cancer Center, Department of Molecular Pathology, for perforn-ing protein sequence analysis. Support for this work came from NIH grant CA 54296a nd, in part, from NIH grant CA 47342 and institutional grant ACS SIG 14. Animal facilities are supported in part by NC1 core grant CA 16672.
PY - 1988
Y1 - 1988
N2 - 1. 1. A 65 kDa-tumor-associated protein (p65) was isolated from human and rat carcinoma cell culture media. Antibodies raised to the rat protein recognized an antigenically related protein in human cancer cell line. 2. 2. Amino acid composition, N-terminal and internal sequence as well as peptide map and western blot analysis of the p65 strongly suggest a high degree of homology between the human and rat p65 proteins. 3. 3. Homology searches indicated that p65 was not homologous to previously sequenced proteins, but that it may be related to proteins of the steroid receptor superfamily of genes, especially c-erb A gene.
AB - 1. 1. A 65 kDa-tumor-associated protein (p65) was isolated from human and rat carcinoma cell culture media. Antibodies raised to the rat protein recognized an antigenically related protein in human cancer cell line. 2. 2. Amino acid composition, N-terminal and internal sequence as well as peptide map and western blot analysis of the p65 strongly suggest a high degree of homology between the human and rat p65 proteins. 3. 3. Homology searches indicated that p65 was not homologous to previously sequenced proteins, but that it may be related to proteins of the steroid receptor superfamily of genes, especially c-erb A gene.
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U2 - 10.1016/0020-711X(88)90318-7
DO - 10.1016/0020-711X(88)90318-7
M3 - Article
C2 - 8138024
AN - SCOPUS:0027787485
SN - 1357-2725
VL - 25
SP - 1865
EP - 1871
JO - International Journal of Biochemistry
JF - International Journal of Biochemistry
IS - 12
ER -