@inproceedings{4de8bee74e014e7a915684121088da48,
title = "Combining Meta- and mega-analytic approaches for multi-site diffusion imaging based genetic studies: From the enigma-DTI working group",
abstract = "Meta-analyses estimate a statistical effect size for a test or an analysis by combining results from multiple studies without necessarily having access to each individual study's raw data. Multi-site meta-analysis is crucial for imaging genetics, as single sites rarely have a sample size large enough to pick up effects of single genetic variants associated with brain measures. However, if raw data can be shared, combining data in a {"}mega-analysis{"} is thought to improve power and precision in estimating global effects. As part of an ENIGMA-DTI investigation, we use fractional anisotropy (FA) maps from 5 studies (total N=2, 203 subjects, aged 9-85) to estimate heritability. We combine the studies through meta-and mega-analyses as well as a mixture of the two - combining some cohorts with mega-analysis and meta-analyzing the results with those of the remaining sites. A combination of mega-and meta-approaches may boost power compared to meta-analysis alone.",
keywords = "DTI, ENIGMA, Heritability, Imaging genetics, Mega-analysis, Meta-analysis, Multi-site",
author = "Neda Jahanshad and Peter Kochunov and Nichols, {Thomas E.} and Emma Sprooten and Mandl, {Ren{\'e} C.} and Almasy, {Laura A} and Brouwer, {Rachel M.} and Curran, {Joanne E} and {De Zubicaray}, {Greig I.} and Rali Dimitrova and Fox, {Peter T.} and Hong, {L. Elliot} and Landman, {Bennett A.} and Herv{\'e} Lemaitre and Lorna Lopez and Martin, {Nicholas G.} and McMahon, {Katie L.} and Mitchell, {Braxton D.} and Olvera, {Rene L.} and Peterson, {Charles P.} and Sussmann, {Jessika E.} and Toga, {Arthur W.} and Wardlaw, {Joanna M.} and Wright, {Margaret J.} and Wright, {Susan N.} and Bastin, {Mark E.} and McIntosh, {Andrew M.} and Boomsma, {Dorret I.} and Kahn, {Ren{\'e} S.} and {Den Braber}, Anouk and Deary, {Ian J.} and Pol, {Hilleke E.Hulshoff} and Williamson, {Douglas E} and Blangero, {John C} and {Van't Ent}, Dennis and Glahn, {David C.} and Thompson, {Paul M.}",
note = "Publisher Copyright: {\textcopyright} 2014 IEEE.; 2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014 ; Conference date: 29-04-2014 Through 02-05-2014",
year = "2014",
month = jul,
day = "29",
doi = "10.1109/isbi.2014.6868099",
language = "English (US)",
series = "2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
pages = "1234--1238",
booktitle = "2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014",
address = "United States",
}