Cognitive efficiency is associated with endogenous cytokine levels in patients with chronic hepatitis C

Robin C Hilsabeck, Gregory M. Anstead, Amy L. Webb, Anastasio Hoyumpa, Paul T Ingmundson, Steve Holliday, Qiong Zhang, Angela M. Casas, Marci Jovel, Stephen L Stern

Producción científica: Articlerevisión exhaustiva

30 Citas (Scopus)

Resumen

The etiology of cognitive dysfunction in chronic hepatitis C (CHC) infection is unknown. Among the possibilities is cytokine activation, which has been associated with cognitive dysfunction in other chronic conditions. The purpose of this study was to investigate the relationship between endogenous IFN-α, IL-6, and TNF-α and cognitive functioning in CHC patients. Seventy-eight veterans with CHC underwent cognitive testing and measurement of serum cytokines. In patients with detectable IFN-α, higher levels of IL-6 and TNF-α were related to poorer cognitive functioning. Findings suggest CHC patients with immune responses characterized by elevated IFN-α may be at risk for cognitive difficulties.

Idioma originalEnglish (US)
Páginas (desde-hasta)53-61
Número de páginas9
PublicaciónJournal of Neuroimmunology
Volumen221
N.º1-2
DOI
EstadoPublished - abr 2010

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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