TY - JOUR
T1 - Clinical Characteristics of Offspring Born to Parents with Type 2 Diabetes Diagnosed in Youth
T2 - Observations from TODAY
AU - on behalf of the TODAY Study Group
AU - Tryggestad, Jeanie B.
AU - Kelsey, Megan M.
AU - Drews, Kimberly L.
AU - Zhou, Shirley
AU - Chang, Nancy
AU - Escaname, Elia
AU - Gidding, Samuel S.
AU - Isganaitis, Elvira
AU - McKay, Siripoom
AU - Shah, Rachana
AU - Van Name, Michelle
N1 - Publisher Copyright:
© 2024 by the authors.
PY - 2024/6
Y1 - 2024/6
N2 - Diabetes exposure during pregnancy affects health outcomes in offspring; however, little is known about in utero exposure to preexisting parental youth-onset type 2 diabetes. Offspring born to participants during the Treatment Options for Type 2 Diabetes in Adolescent and Youth (TODAY) study were administered a questionnaire at the end of the study. Of 457 participants, 37% of women and 18% of men reported 228 offspring, 80% from female participants. TODAY mothers had lower household income (<$25,000) compared to TODAY fathers (69.4% vs. 37.9%, p = 0.0002). At 4.5 years of age (range 0–18 years), 16.7% of offspring were overweight according to the parental report of their primary care provider, with no sex difference. Offspring of TODAY mothers reported more daily medication use compared to TODAY fathers (50/183, 27.7% vs. 6/46, 12.2%, [p = 0.04]), a marker of overall health. TODAY mothers also reported higher rates of recidivism (13/94) than TODAY fathers (0/23). An Individualized Education Plan was reported in 20/94 (21.3%) offspring of TODAY mothers compared to 2/23 (8.7%) of TODAY fathers. This descriptive study, limited by parental self-reports, indicated offspring of participants in TODAY experience significant socioeconomic disadvantages, which, when combined with in utero diabetes exposure, may increase their risk of health and educational disparities.
AB - Diabetes exposure during pregnancy affects health outcomes in offspring; however, little is known about in utero exposure to preexisting parental youth-onset type 2 diabetes. Offspring born to participants during the Treatment Options for Type 2 Diabetes in Adolescent and Youth (TODAY) study were administered a questionnaire at the end of the study. Of 457 participants, 37% of women and 18% of men reported 228 offspring, 80% from female participants. TODAY mothers had lower household income (<$25,000) compared to TODAY fathers (69.4% vs. 37.9%, p = 0.0002). At 4.5 years of age (range 0–18 years), 16.7% of offspring were overweight according to the parental report of their primary care provider, with no sex difference. Offspring of TODAY mothers reported more daily medication use compared to TODAY fathers (50/183, 27.7% vs. 6/46, 12.2%, [p = 0.04]), a marker of overall health. TODAY mothers also reported higher rates of recidivism (13/94) than TODAY fathers (0/23). An Individualized Education Plan was reported in 20/94 (21.3%) offspring of TODAY mothers compared to 2/23 (8.7%) of TODAY fathers. This descriptive study, limited by parental self-reports, indicated offspring of participants in TODAY experience significant socioeconomic disadvantages, which, when combined with in utero diabetes exposure, may increase their risk of health and educational disparities.
KW - diabetes
KW - medication use
KW - obesity
KW - perinatal complications
KW - recidivism
UR - http://www.scopus.com/inward/record.url?scp=85197170849&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85197170849&partnerID=8YFLogxK
U2 - 10.3390/children11060630
DO - 10.3390/children11060630
M3 - Article
C2 - 38929210
AN - SCOPUS:85197170849
SN - 2227-9067
VL - 11
JO - Children
JF - Children
IS - 6
M1 - 630
ER -