Clinical and laboratory factors associated with interstitial lung disease in rheumatoid arthritis

José Félix Restrepo, Inmaculada del Rincón, Daniel F. Battafarano, Roy W. Haas, Merced Doria, Agustín Escalante

Resultado de la investigación: Articlerevisión exhaustiva

57 Citas (Scopus)


Objective: The objective of this study is to examine the clinical, genetic, and environmental factors associated with interstitial lung disease (ILD) in rheumatoid arthritis (RA). Method: We recruited patients with RA from rheumatology practices at the time of a scheduled visit. Each patient participated in a comprehensive assessment that included ascertainment of age, sex, joint tenderness and swelling, subcutaneous nodules, disease severity, use of methotrexate and prednisone, smoking status, rheumatoid factor (RF), antibodies against cyclic citrullinated peptide (anti-CCP),erythrocyte sedimentation rate (ESR), the 28-joint Disease Activity Score (DAS28), and the presence of the HLA–DRB1 shared epitope (SE). As part of a thorough quantification of comorbidity, we identify all comorbid conditions, including ILD. We examined variables associated with ILD using logistic regression. We tested interaction terms between SE and other covariates. Results: We studied 779 RA patients, among whom, ILD was recognized clinically in 69 (8.8 %). Variables significantly associated with ILD in a multivariable analysis included male sex, RA duration, the ESR, the DAS28, anti-CCP, and RF. There was a significant interaction between the HLA–DRB1 SE and smoking, ILD being associated with smoking only in the presence of SE. The association between ILD and anti-CCP, RF, and the ESR displayed a biological gradient, higher titers being more strongly associated with ILD. Conclusion: Anti-CCP antibodies and the RF may be pathogenically related to ILD. The association between ILD and smoking is dependent on the HLA–DRB1 SE, which may reflect gene–environment interaction.

Idioma originalEnglish (US)
Páginas (desde-hasta)1529-1536
Número de páginas8
PublicaciónClinical Rheumatology
EstadoPublished - sept 26 2015

ASJC Scopus subject areas

  • Rheumatology


Profundice en los temas de investigación de 'Clinical and laboratory factors associated with interstitial lung disease in rheumatoid arthritis'. En conjunto forman una huella única.

Citar esto