TY - JOUR
T1 - Clinical and Echocardiographic Correlates of Left Atrial Function Index
T2 - The Framingham Offspring Study
AU - Sardana, Mayank
AU - Nah, Gregory
AU - Tsao, Connie W.
AU - Ogunsua, Adedotun A.
AU - Vittinghoff, Eric
AU - Thomas, Randell C.
AU - Cheng, Susan
AU - Vaze, Aditya
AU - Aragam, Jayashri R.
AU - Mitchell, Gary F.
AU - Benjamin, Emelia J.
AU - Vasan, Ramachandran S.
AU - Aurigemma, Gerard P.
AU - Schiller, Nelson B.
AU - McManus, David D.
AU - Parikh, Nisha I.
N1 - Funding Information:
The study was funded by grants HHSN268201500001I (to R.S.V.), N01-HC 25195 (to R.S.V.), 1R01HL128914 (to E.J.B.), and 2R01 HL092577 (to E.J.B.) from the National Institutes of Health and National Heart, Lung, and Blood Institute. The funders of the study had no role in the study design, data collection, data analysis, data interpretation, writing of the report, or the decision to submit the article for publication.
Publisher Copyright:
© 2017 American Society of Echocardiography
PY - 2017/9
Y1 - 2017/9
N2 - Background Left atrial (LA) remodeling is a predictor of cardiovascular disease (CVD). We performed measurement of the LA function index (LAFI), a composite measure of LA structure and function, in a community-based cohort and here report the distribution and cross-sectional correlates of LAFI. Methods In 1,719 Framingham Offspring Study participants (54% women, mean age 66 ± 9 years), we derived LAFI from the LA emptying fraction, left ventricular (LV) outflow tract velocity time integral, and indexed maximal LA volume. We used multivariable linear regression to assess the clinical and echocardiographic correlates of LAFI adjusting for age, sex, anthropometric measurements, and CVD risk factors. Results The average LAFI was 35.2 ± 12.1. Overall, LAFI declined with advancing age (β = −0.27, P <.001). LAFI was significantly higher (37.5 ± 11.6) in a subgroup of participants free of CVD and CVD risk factors compared with those with either of these conditions (34.5 ± 12.2). In multivariable models, LAFI was inversely related to antihypertensive use (β = −1.26, P =.038), prevalent atrial fibrillation (β = −4.46, P =.001), heart failure (β = −5.86, P =.008), and coronary artery disease (β = −2.01, P =.046). In models adjusting for echocardiographic variables, LAFI was directly related to LV ejection fraction (β = 14.84, P <.001) and inversely related to LV volume (β = −7.03, P <.001). Conclusions LAFI was inversely associated with antihypertensive use and prevalent CVD and was related to established echocardiographic traits of LV remodeling. Our results offer normative ranges for LAFI in a white community-based sample and suggest that LAFI represents a marker of pathological atrial remodeling.
AB - Background Left atrial (LA) remodeling is a predictor of cardiovascular disease (CVD). We performed measurement of the LA function index (LAFI), a composite measure of LA structure and function, in a community-based cohort and here report the distribution and cross-sectional correlates of LAFI. Methods In 1,719 Framingham Offspring Study participants (54% women, mean age 66 ± 9 years), we derived LAFI from the LA emptying fraction, left ventricular (LV) outflow tract velocity time integral, and indexed maximal LA volume. We used multivariable linear regression to assess the clinical and echocardiographic correlates of LAFI adjusting for age, sex, anthropometric measurements, and CVD risk factors. Results The average LAFI was 35.2 ± 12.1. Overall, LAFI declined with advancing age (β = −0.27, P <.001). LAFI was significantly higher (37.5 ± 11.6) in a subgroup of participants free of CVD and CVD risk factors compared with those with either of these conditions (34.5 ± 12.2). In multivariable models, LAFI was inversely related to antihypertensive use (β = −1.26, P =.038), prevalent atrial fibrillation (β = −4.46, P =.001), heart failure (β = −5.86, P =.008), and coronary artery disease (β = −2.01, P =.046). In models adjusting for echocardiographic variables, LAFI was directly related to LV ejection fraction (β = 14.84, P <.001) and inversely related to LV volume (β = −7.03, P <.001). Conclusions LAFI was inversely associated with antihypertensive use and prevalent CVD and was related to established echocardiographic traits of LV remodeling. Our results offer normative ranges for LAFI in a white community-based sample and suggest that LAFI represents a marker of pathological atrial remodeling.
KW - Atrial fibrillation
KW - Cardiovascular diseases
KW - Echocardiography
KW - Epidemiology
KW - Left atrial function
KW - Left atrial function index
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U2 - 10.1016/j.echo.2017.05.013
DO - 10.1016/j.echo.2017.05.013
M3 - Article
C2 - 28735892
AN - SCOPUS:85025432698
VL - 30
SP - 904-912.e2
JO - Journal of the American Society of Echocardiography
JF - Journal of the American Society of Echocardiography
SN - 0894-7317
IS - 9
ER -