Circulatory half-life time of artificial red blood cell (hemoglobin-vesicles) and their distribution to metabolic organs

Keitaro Sou, Beth Goins, William T. Phillips, Hiromi Sakai, Shinji Takeoka, Eishun Tsuchida

Resultado de la investigación: Paperrevisión exhaustiva


Phospholipid vesicles encapsulating concentrated human hemoglobin (Hb-vesicles: HbV) have a membrane structure similar to that of red blood cells (RBC). We report the pharmacokinetics of HbV and empty vesicles (EV) that do not contain Hb, in rats and rabbits to evaluate the potential of HbV as a RBC substitute. The samples were labeled with technetium-99m (99mTc), and then intravenously infused into animals at 14 mL/kg to measure the kinetics of HbV elimination from blood and distribution to the organs. The circulation half-life times were 34.8 and 62.6 h for HbV, and 29.3 and 57.3 h for EV in rats and rabbits, respectively. At 48 h after infusion, the liver and spleen of both rats and rabbits had significant concentrations of HbV and EV. These organs would be reasonable to metabolize HbV because they have mononuclear phagocyte systems to introduce the red blood cells into metabolic process.

Idioma originalEnglish (US)
Número de páginas1
EstadoPublished - dic 1 2005
Evento54th SPSJ Annual Meeting 2005 - Yokohama, Japan
Duración: may 25 2005may 27 2005


Other54th SPSJ Annual Meeting 2005

ASJC Scopus subject areas

  • Engineering(all)


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