TY - JOUR
T1 - Circulating Tumor Cells in Gastrointestinal Cancer
T2 - Current Practices and Future Directions
AU - Court, Colin M.
AU - Ankeny, Jacob S.
AU - Sho, Shonan
AU - Tomlinson, James S.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - GI cancers are the leading cause of cancer-related death worldwide primarily due to a combination of late presentation and aggressive biology. The lack of adequate biomarkers for screening, diagnosis, staging, and prognosis confounds clinical decision-making and delays potentially effective therapies. Circulating tumor cells (CTCs) are a new biomarker with particular promise in GI cancers, potentially offering clinicians and researchers real-time access to tumor tissue in a reliable, safe, and cost-effective manner. Preliminary studies have investigated the potential clinical utility of CTCs for all GI cancer types with promising results. Furthermore, advances in single cell analytics have been successfully applied to CTCs, allowing for exciting new clinical and research applications. In this chapter, we will review the current state of CTC research in GI cancers as well as the potential future applications that are currently being developed.
AB - GI cancers are the leading cause of cancer-related death worldwide primarily due to a combination of late presentation and aggressive biology. The lack of adequate biomarkers for screening, diagnosis, staging, and prognosis confounds clinical decision-making and delays potentially effective therapies. Circulating tumor cells (CTCs) are a new biomarker with particular promise in GI cancers, potentially offering clinicians and researchers real-time access to tumor tissue in a reliable, safe, and cost-effective manner. Preliminary studies have investigated the potential clinical utility of CTCs for all GI cancer types with promising results. Furthermore, advances in single cell analytics have been successfully applied to CTCs, allowing for exciting new clinical and research applications. In this chapter, we will review the current state of CTC research in GI cancers as well as the potential future applications that are currently being developed.
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U2 - 10.1007/978-3-319-34244-3_17
DO - 10.1007/978-3-319-34244-3_17
M3 - Review article
C2 - 29206383
AN - SCOPUS:85021648905
SN - 0927-3042
VL - 168
SP - 345
EP - 376
JO - Cancer treatment and research
JF - Cancer treatment and research
ER -