Circulating insulin-like growth factor-1 and its binding protein-3: Metabolic and genetic correlates in the community

Carolyn S.P. Lam, Ming Huei Chen, Sean M. Lacey, Qiong Yang, Lisa M. Sullivan, Vanessa Xanthakis, Radwan Safa, Holly M. Smith, Xuyang Peng, Douglas B. Sawyer, Ramachandran S. Vasan

Resultado de la investigación: Articlerevisión exhaustiva

75 Citas (Scopus)

Resumen

Objective-: The metabolic and genetic correlates of circulating insulin-like growth factor-1 (IGF-1) and its main circulating carrier, IGF-1-binding-protein-3 (IGFBP-3), are unclear. Methods and Results-: We measured serum IGF-1 and IGFBP-3 concentrations in a sample of the Framingham Heart Study (N=3977, aged 40±9 years, 46% male) and evaluated their relations to cardiovascular risk factors using multivariable regression. Serum IGF-1 was inversely correlated with age, body mass index, total cholesterol, the presence of diabetes, alcohol consumption, and glomerular filtration rate (all P<0.01), whereas the ratio of IGF-1:IGFBP-3 was lower in women and inversely related to age, triglycerides, high-density lipoprotein cholesterol, systolic blood pressure, and alcohol consumption (all P<0.0001). Circulating IGF-1 correlated negatively with insulin resistance (homeostatic model assessment) (r=-0.1; P<0.0001) and was lower in participants with more components of the metabolic syndrome (Adult Treatment Panel III criteria) (P<0.0001). Additive genetic factors (heritability) accounted for 43% and 39% of the variation of IGF-1 and IGFBP-3, respectively (both P<10). Conclusion-: Our cross-sectional observations in a large community-based sample link lower circulating IGF-1 to greater metabolic risk burden and underscore substantial genetic influences on IGF-1 concentrations. Prospective studies are warranted to elucidate whether lower IGF-1 concentrations predict greater metabolic risk longitudinally.

Idioma originalEnglish (US)
Páginas (desde-hasta)1479-1484
Número de páginas6
PublicaciónArteriosclerosis, Thrombosis, and Vascular Biology
Volumen30
N.º7
DOI
EstadoPublished - jul. 2010
Publicado de forma externa

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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