Chromosomal aberrations in tuberculosis patients before and after treatment with short-term chemotherapy

V. V.N. Gopal Rao, E. V. Venkatarama Gupta, I. M. Thomas

Producción científica: Articlerevisión exhaustiva

19 Citas (Scopus)

Resumen

Cytogenetic effects of 4 common anti-tubercular drugs, isoniazid (H), streptomycin (S), rifampicin (R) and pyrazinamide (Z), in 3 different combinations (2 SHRZ, 2 HRZ and 2 H2R2Z2) were evaluated in the lymphocytes of tuberculosis patients undergoing chemotherapy, in order to estimate their mutagenic potential in combination. All 3 regimens showed an increased frequency of chromosomal aberrations after treatment compared to before treatment. These findings are of significance in the treatment of tuberculosis, as the drugs in question are observed to be mutagenic/clastogenic.

Idioma originalEnglish (US)
Páginas (desde-hasta)13-19
Número de páginas7
PublicaciónMutation Research/Genetic Toxicology
Volumen259
N.º1
DOI
EstadoPublished - ene 1991
Publicado de forma externa

ASJC Scopus subject areas

  • Genetics
  • Toxicology

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