Chlorpromazine metabolism II: Determination of nonconjugated metabolites in blood of schizophrenic patients

Pushkar N. Kaul; Michael W. Conway; Maharaj K. Ticku; Mervin L. Clark

doi:10.1002/jps.2600610418

Chlorpromazine metabolism II: Determination of nonconjugated metabolites in blood of schizophrenic patients

Pushkar N. Kaul, Michael W. Conway, Maharaj K. Ticku, Mervin L. Clark

Resultado de la investigación: Article › revisión exhaustiva

13 Citas (Scopus)

Resumen

A previously described dansylation method of quantitation was applied to determine the circulating levels of chlorpromazine metabolites in humans. Localization of the metabolites within the erythrocytes suggests that the whole hemolyzed blood be used for analyses. An optimum procedure of assay was developed which makes it possible, for the first time, to determine 11 metabolites in blood simultaneously. Blood level data from hospitalized chronic schizophrenic patients receiving variable doses of chlorpromazine are included.

Idioma original	English (US)
Páginas (desde-hasta)	581-585
Número de páginas	5
Publicación	Journal of Pharmaceutical Sciences
Volumen	61
N.º	4
DOI	https://doi.org/10.1002/jps.2600610418
Estado	Published - abr 1972
Publicado de forma externa	Sí

ASJC Scopus subject areas

Pharmaceutical Science

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10.1002/jps.2600610418

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title = "Chlorpromazine metabolism II: Determination of nonconjugated metabolites in blood of schizophrenic patients",

abstract = "A previously described dansylation method of quantitation was applied to determine the circulating levels of chlorpromazine metabolites in humans. Localization of the metabolites within the erythrocytes suggests that the whole hemolyzed blood be used for analyses. An optimum procedure of assay was developed which makes it possible, for the first time, to determine 11 metabolites in blood simultaneously. Blood level data from hospitalized chronic schizophrenic patients receiving variable doses of chlorpromazine are included.",

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author = "Kaul, {Pushkar N.} and Conway, {Michael W.} and Ticku, {Maharaj K.} and Clark, {Mervin L.}",

year = "1972",

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doi = "10.1002/jps.2600610418",

language = "English (US)",

volume = "61",

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T2 - Determination of nonconjugated metabolites in blood of schizophrenic patients

AU - Kaul, Pushkar N.

AU - Conway, Michael W.

AU - Ticku, Maharaj K.

AU - Clark, Mervin L.

PY - 1972/4

Y1 - 1972/4

N2 - A previously described dansylation method of quantitation was applied to determine the circulating levels of chlorpromazine metabolites in humans. Localization of the metabolites within the erythrocytes suggests that the whole hemolyzed blood be used for analyses. An optimum procedure of assay was developed which makes it possible, for the first time, to determine 11 metabolites in blood simultaneously. Blood level data from hospitalized chronic schizophrenic patients receiving variable doses of chlorpromazine are included.

AB - A previously described dansylation method of quantitation was applied to determine the circulating levels of chlorpromazine metabolites in humans. Localization of the metabolites within the erythrocytes suggests that the whole hemolyzed blood be used for analyses. An optimum procedure of assay was developed which makes it possible, for the first time, to determine 11 metabolites in blood simultaneously. Blood level data from hospitalized chronic schizophrenic patients receiving variable doses of chlorpromazine are included.

KW - Chlorpromazine metabolism—determination of 11 nonconjugated metabolites in the blood of schizophrenic patients, TLC, fluorometry

KW - Fluorometry—analysis, chlorpromazine metabolites in blood

KW - Schizophrenics' chlorpromazine blood levels—determination of 11 nonconjugated metabolites, TLC, fluorometry

KW - TLC—separation

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DO - 10.1002/jps.2600610418

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SN - 0022-3549

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JO - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

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Chlorpromazine metabolism II: Determination of nonconjugated metabolites in blood of schizophrenic patients

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