Chlamydia trachomatis infection inhibits both Bax and Bak activation induced by staurosporine

Yangming Xiao, Youmin Zhong, Whitney Greene, Feng Dong, Guangming Zhong

Producción científica: Articlerevisión exhaustiva

71 Citas (Scopus)

Resumen

We have previously shown that Chlamydia trachomatis inhibits host cell apoptosis and blocks mitochondrial cytochrome c release. We now report that activation of both Bax and Bak, two proapoptotic members of the Bcl-2 family that regulate mitochondrial cytochrome c release, was inhibited in chlamydia-infected cells. This observation has provided new information on the mechanisms of chlamydial antiapoptotic activity.

Idioma originalEnglish (US)
Páginas (desde-hasta)5470-5474
Número de páginas5
PublicaciónInfection and immunity
Volumen72
N.º9
DOI
EstadoPublished - sept 2004

ASJC Scopus subject areas

  • Infectious Diseases
  • Parasitology
  • Microbiology
  • Immunology

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