Chlamydia trachomatis infection inhibits both Bax and Bak activation induced by staurosporine

Yangming Xiao; Youmin Zhong; Whitney Greene; Feng Dong; Guangming Zhong

doi:10.1128/IAI.72.9.5470-5474.2004

Chlamydia trachomatis infection inhibits both Bax and Bak activation induced by staurosporine

Yangming Xiao, Youmin Zhong, Whitney Greene, Feng Dong, Guangming Zhong

Department of Microbiology, Immunology & Molecular Genetics

Producción científica: Article › revisión exhaustiva

70 Citas (Scopus)

Resumen

We have previously shown that Chlamydia trachomatis inhibits host cell apoptosis and blocks mitochondrial cytochrome c release. We now report that activation of both Bax and Bak, two proapoptotic members of the Bcl-2 family that regulate mitochondrial cytochrome c release, was inhibited in chlamydia-infected cells. This observation has provided new information on the mechanisms of chlamydial antiapoptotic activity.

Idioma original	English (US)
Páginas (desde-hasta)	5470-5474
Número de páginas	5
Publicación	Infection and immunity
Volumen	72
N.º	9
DOI	https://doi.org/10.1128/IAI.72.9.5470-5474.2004
Estado	Published - sept 2004

ASJC Scopus subject areas

Infectious Diseases
Parasitology
Microbiology
Immunology

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title = "Chlamydia trachomatis infection inhibits both Bax and Bak activation induced by staurosporine",

abstract = "We have previously shown that Chlamydia trachomatis inhibits host cell apoptosis and blocks mitochondrial cytochrome c release. We now report that activation of both Bax and Bak, two proapoptotic members of the Bcl-2 family that regulate mitochondrial cytochrome c release, was inhibited in chlamydia-infected cells. This observation has provided new information on the mechanisms of chlamydial antiapoptotic activity.",

author = "Yangming Xiao and Youmin Zhong and Whitney Greene and Feng Dong and Guangming Zhong",

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AU - Greene, Whitney

AU - Dong, Feng

AU - Zhong, Guangming

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AB - We have previously shown that Chlamydia trachomatis inhibits host cell apoptosis and blocks mitochondrial cytochrome c release. We now report that activation of both Bax and Bak, two proapoptotic members of the Bcl-2 family that regulate mitochondrial cytochrome c release, was inhibited in chlamydia-infected cells. This observation has provided new information on the mechanisms of chlamydial antiapoptotic activity.

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Chlamydia trachomatis infection inhibits both Bax and Bak activation induced by staurosporine

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