Chemotherapy of childhood rhabdomyosarcomas growing as xenografts in immune-deprived mice

Janet A. Houghton, Peter J. Houghton, Alexander A. Green

Producción científica: Articlerevisión exhaustiva

32 Citas (Scopus)


Xenografts derived from the neoplastic tissues of children with rhabdomyosarcoma have been used in immune-deprived mice to examine the efficacy of agents known to be active against this disease, and in others that received either limited of no clinical evaluation. Two models were derived; xenografts were established from tumors obtained from either (a) untreated patients or (b) from patients who had become refractory to conventional therapy. Model a identified as being effective each of these clinically used agents: vincristine, dactinomycin, cyclophosphamide, and doxorubicin; mitomycin C and 5-(3,3-dimethyl-1 -triazeno)-2-methylimidazole-4-carboxamide also showed activity, as did busulfan in one tumor line. Tumors derived from refractory patients were significantly less responsive to all agents examined.

Idioma originalEnglish (US)
Páginas (desde-hasta)535-539
Número de páginas5
PublicaciónCancer Research
EstadoPublished - feb 1 1982
Publicado de forma externa

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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