Characterization of uvi15+, a stress-inducible gene from Schizosaccharomyces pombe

Joon Kyu Lee, Minkyu Kim, Joonho Choe, Rho Hyun Seong, Seung Hwan Hong, Sang Dai Park

Producción científica: Articlerevisión exhaustiva

15 Citas (Scopus)


The uvi15+ gene of Schizosaccharomyces pombe is a member of a group of stress-inducible genes transcription levels of which increase in response to DNA-damaging agents or heat shock. It encodes a polypeptide of calculated molecular mass 11641 Da, with no significant sequence similarity to other known heat shock proteins. The steady-state level of the uvi15+ gene product of about 12 kDa was increased by heat shock and canavanine, an amino acid analog. This gene also showed a transient increase in expression as cells moved into diauxic shift phase. Although deletion of the uvi15+ gene did not affect the mitotic growth or thermotolerance of cells, the mutant cells rapidly lost viability in stationary phase and under starvation conditions. These cells also showed a defect in sporulation ability. These results suggest that the uvi15+ gene encodes a stress response protein involved in the maintenance of cell viability during entry into stationary phase or under starvation conditions.

Idioma originalEnglish (US)
Páginas (desde-hasta)663-670
Número de páginas8
PublicaciónMGG Molecular & General Genetics
EstadoPublished - nov 1995
Publicado de forma externa

ASJC Scopus subject areas

  • Genetics


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