Characterization of the interaction between the saccharomyces cerevisiae Rad51 recombinase and the DNA translocase Rdh54

Sergio R.Santa Maria, Young Ho Kwon, Patrick Sung, Hannah L. Klein

Producción científica: Articlerevisión exhaustiva

11 Citas (Scopus)

Resumen

Background: Rdh54 is a motor protein that is able to dissociate Rad51 recombinase from chromatin. Results: The Rad51-binding domain of Rdh54 resides within its N terminus and is required for Rad51 removal from DNA. Conclusion: Rdh54-Rad51 interaction is important for Rad51 dissociation from chromatin but not for DNA repair. Significance: Rdh54 inhibits accumulation of toxic Rad51-DNA complexes.

Idioma originalEnglish (US)
Páginas (desde-hasta)21999-22005
Número de páginas7
PublicaciónJournal of Biological Chemistry
Volumen288
N.º30
DOI
EstadoPublished - jul 26 2013
Publicado de forma externa

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry
  • Cell Biology

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