Chapter 2 Genetics of the Framingham Heart Study Population

Diddahally R. Govindaraju, L. Adrienne Cupples, William B. Kannel, Christopher J. O'Donnell, Larry D. Atwood, Ralph B. D'Agostino, Caroline S. Fox, Marty Larson, Daniel Levy, Joanne Murabito, Ramachandran S. Vasan, Greta Lee Splansky, Philip A. Wolf, Emelia J. Benjamin

Producción científica: Chapter

72 Citas (Scopus)

Resumen

This chapter provides an introduction to the Framingham Heart Study and the genetic research related to cardiovascular diseases conducted in this unique population. It briefly describes the origins of the study, the risk factors that contribute to heart disease, and the approaches taken to discover the genetic basis of some of these risk factors. The genetic architecture of several biological risk factors has been explained using family studies, segregation analysis, heritability, and phenotypic and genetic correlations. Many quantitative trait loci underlying cardiovascular diseases have been discovered using different molecular markers. Additionally, initial results from genome-wide association studies using 116,000 markers and the prospects of using 550,000 markers for association studies are presented. Finally, the use of this unique sample to study genotype and environment interactions is described.

Idioma originalEnglish (US)
Título de la publicación alojadaAdvances in Genetics
EditoresJeffrey Hall
Páginas33-65
Número de páginas33
DOI
EstadoPublished - 2008
Publicado de forma externa

Serie de la publicación

NombreAdvances in Genetics
Volumen62
ISSN (versión impresa)0065-2660

ASJC Scopus subject areas

  • Genetics

Huella

Profundice en los temas de investigación de 'Chapter 2 Genetics of the Framingham Heart Study Population'. En conjunto forman una huella única.

Citar esto