Changes in lipid composition of cortical synaptosomes from different age groups of mice

W. G. Wood; R. Strong; L. S. Williamson; R. W. Wise

doi:10.1016/0024-3205(84)90475-2

Changes in lipid composition of cortical synaptosomes from different age groups of mice

W. G. Wood, R. Strong, L. S. Williamson, R. W. Wise

Producción científica: Article › revisión exhaustiva

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Resumen

Lipid composition of cortical synaptosomes differed with age in C57BL/6NNIA mice. Significant age differences were observed for cholesterol and the ratio of cholesterol to total phospholipid phosphorus content. The phospholipid to protein ratio of individual phospholipids also increased with age with diacyl-sn-glycero-3-phosphocholine (PC) increasing the most. Acyl group composition of individual phospholipids, however, showed little age difference. The double bond index for PC decreased significantly with age. Changes in membrane composition may help explain differences in the effects of ethanol on the physical and biochemical properties of membranes from different age groups that have been reported previously.

Idioma original	English (US)
Páginas (desde-hasta)	1947-1952
Número de páginas	6
Publicación	Life Sciences
Volumen	35
N.º	19
DOI	https://doi.org/10.1016/0024-3205(84)90475-2
Estado	Published - nov 5 1984
Publicado de forma externa	Sí

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry, Genetics and Molecular Biology

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10.1016/0024-3205(84)90475-2

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title = "Changes in lipid composition of cortical synaptosomes from different age groups of mice",

abstract = "Lipid composition of cortical synaptosomes differed with age in C57BL/6NNIA mice. Significant age differences were observed for cholesterol and the ratio of cholesterol to total phospholipid phosphorus content. The phospholipid to protein ratio of individual phospholipids also increased with age with diacyl-sn-glycero-3-phosphocholine (PC) increasing the most. Acyl group composition of individual phospholipids, however, showed little age difference. The double bond index for PC decreased significantly with age. Changes in membrane composition may help explain differences in the effects of ethanol on the physical and biochemical properties of membranes from different age groups that have been reported previously.",

author = "Wood, {W. G.} and R. Strong and Williamson, {L. S.} and Wise, {R. W.}",

note = "Funding Information: The research was supported by the Medical Research Service of the Veterans Administration and the Geriatric Research, Education, and Clinical Center of the Veterans Administration Medical Center, St. Louis~ MO. The authors gratefully acknowledge the excellent secretarial assistance of Mrs. Sandy Melliere and Mrs. Cheryl Duff.",

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doi = "10.1016/0024-3205(84)90475-2",

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T1 - Changes in lipid composition of cortical synaptosomes from different age groups of mice

AU - Wood, W. G.

AU - Strong, R.

AU - Williamson, L. S.

AU - Wise, R. W.

N1 - Funding Information: The research was supported by the Medical Research Service of the Veterans Administration and the Geriatric Research, Education, and Clinical Center of the Veterans Administration Medical Center, St. Louis~ MO. The authors gratefully acknowledge the excellent secretarial assistance of Mrs. Sandy Melliere and Mrs. Cheryl Duff.

PY - 1984/11/5

Y1 - 1984/11/5

N2 - Lipid composition of cortical synaptosomes differed with age in C57BL/6NNIA mice. Significant age differences were observed for cholesterol and the ratio of cholesterol to total phospholipid phosphorus content. The phospholipid to protein ratio of individual phospholipids also increased with age with diacyl-sn-glycero-3-phosphocholine (PC) increasing the most. Acyl group composition of individual phospholipids, however, showed little age difference. The double bond index for PC decreased significantly with age. Changes in membrane composition may help explain differences in the effects of ethanol on the physical and biochemical properties of membranes from different age groups that have been reported previously.

AB - Lipid composition of cortical synaptosomes differed with age in C57BL/6NNIA mice. Significant age differences were observed for cholesterol and the ratio of cholesterol to total phospholipid phosphorus content. The phospholipid to protein ratio of individual phospholipids also increased with age with diacyl-sn-glycero-3-phosphocholine (PC) increasing the most. Acyl group composition of individual phospholipids, however, showed little age difference. The double bond index for PC decreased significantly with age. Changes in membrane composition may help explain differences in the effects of ethanol on the physical and biochemical properties of membranes from different age groups that have been reported previously.

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Changes in lipid composition of cortical synaptosomes from different age groups of mice

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