TY - JOUR
T1 - Challenges and opportunities to the design and implementation of chemoprevention trials for prostate cancer
AU - Thompson, Ian M
AU - Basler, Joseph A.
AU - Leach, Robin
AU - Troyer, Dean
AU - Klein, Eric
AU - Brawley, Otis
PY - 2003/1
Y1 - 2003/1
N2 - Since 1991 and the activation of the Prostate Cancer Prevention Trial as well as similar prevention studies in several other organ sites, the interest in prostate cancer prevention has increased substantially. Despite such interest, the challenges to prevention trials-in design, implementation, prioritization, and allocation of resources-are substantial. Simultaneously, there has been an explosion in new targets and agents that may have an effect in the prevention of this disease. In this manuscript, we discuss these challenges to the study of prostate cancer prevention and provide a blueprint for prioritization of future studies.
AB - Since 1991 and the activation of the Prostate Cancer Prevention Trial as well as similar prevention studies in several other organ sites, the interest in prostate cancer prevention has increased substantially. Despite such interest, the challenges to prevention trials-in design, implementation, prioritization, and allocation of resources-are substantial. Simultaneously, there has been an explosion in new targets and agents that may have an effect in the prevention of this disease. In this manuscript, we discuss these challenges to the study of prostate cancer prevention and provide a blueprint for prioritization of future studies.
UR - https://www.scopus.com/pages/publications/0141888148
UR - https://www.scopus.com/inward/citedby.url?scp=0141888148&partnerID=8YFLogxK
U2 - 10.1016/S1078-1439(02)00302-2
DO - 10.1016/S1078-1439(02)00302-2
M3 - Article
C2 - 12684131
AN - SCOPUS:0141888148
SN - 1078-1439
VL - 21
SP - 73
EP - 78
JO - Urologic Oncology: Seminars and Original Investigations
JF - Urologic Oncology: Seminars and Original Investigations
IS - 1
ER -