TY - JOUR
T1 - Chain-reaction, a model of gene expression dynamics
AU - Chen, Yidong
N1 - Publisher Copyright:
© 2011 - 2016 Translational Cancer Research. All rights reserved.
PY - 2012/8/1
Y1 - 2012/8/1
N2 - One of the fundamental studies of transcription response to stimuli is to model the activation, repression of hundreds of genes, and their regulations. To further complicate the scenario, genes are regulated by multiple transcription factors, operating through different modes (earlier activation or secondary response). Thus, to fully understand the transcription response, a static analysis indicating which genes are induced at one given time point is not suffi cient. Therefore, it is crucial to analyze the transcriptional dynamics in a systemic manner.
AB - One of the fundamental studies of transcription response to stimuli is to model the activation, repression of hundreds of genes, and their regulations. To further complicate the scenario, genes are regulated by multiple transcription factors, operating through different modes (earlier activation or secondary response). Thus, to fully understand the transcription response, a static analysis indicating which genes are induced at one given time point is not suffi cient. Therefore, it is crucial to analyze the transcriptional dynamics in a systemic manner.
UR - http://www.scopus.com/inward/record.url?scp=84962725943&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84962725943&partnerID=8YFLogxK
U2 - 10.3978/j.issn.2218-676X.2012.06.01
DO - 10.3978/j.issn.2218-676X.2012.06.01
M3 - Editorial
AN - SCOPUS:84962725943
SN - 2218-676X
VL - 1
SP - 59
EP - 60
JO - Translational Cancer Research
JF - Translational Cancer Research
IS - 2
ER -