@article{ad2d5e134ca8460c8bc34374057c95b6,
title = "Cerebrospinal fluid HVA, central brain atrophy, and clinical state in schizophrenia",
abstract = "In 16 patients with chronic schizophrenia, cerebrospinal fluid (CSF) concentrations of homovanillic acid (HVA) showed a significant negative correlation with computed tomographic measures of brain third ventricle size. Clinical state during a drug-free period was also significantly correlated with CSF HVA level, but not with third ventricle size when the effect of CSF HVA was partialed out. The authors propose that these findings may reflect an atrophic process involving structures around the third ventricle and a decrease in dopaminergic activity.",
keywords = "Schizophrenia, brain atrophy, computed tomography, homovanillic acid",
author = "Houston, {John P.} and Maas, {James W.} and Bowden, {Charles L.} and Contreras, {Salvador A.} and McIntyre, {Kathryn L.} and Javors, {Martin A.}",
note = "Funding Information: Acknowledgments. This work was supported by VA Medical Research Funds, Mary Yates Memorial Fund through The Hogg Foundation for Mental Health, The University of Texas, and NIM H Grant No. M H-40935-0I . We thank the staff of Unit I-C and the Radiology Service of the Audie L. Murphy Memorial Veterans Hospital for their active participation and assistancei n this research; and C.D. Taylor for technical assistancei n HVA assays.",
year = "1986",
month = nov,
doi = "10.1016/0165-1781(86)90099-5",
language = "English (US)",
volume = "19",
pages = "207--214",
journal = "Psychiatry Research",
issn = "0165-1781",
publisher = "Elsevier Ireland Ltd",
number = "3",
}