Central Adiposity and Cortical Thickness in Midlife

Sonya Kaur, Mitzi M. Gonzales, Barbara Strasser, Evan Pasha, Jasmine McNeely, Hirofumi Tanaka, Andreana P. Haley

Producción científica: Articlerevisión exhaustiva

29 Citas (Scopus)


Objectives Excessive visceral fat is associated with greater metabolic fluctuation and increased risk for dementia in older adults. The aim of the current study is to directly determine the impact of central adiposity on brain structure at midlife by examining the thickness of the cerebral cortex. Methods High-resolution magnetization-prepared rapid acquisition gradient-echo images were obtained from 103 participants aged 40 to 60 years (mean [standard deviation] = 49.63 [6.47] years) on a 3-T Siemens Skyra scanner. Visceral fat was measured using dual-energy x-ray absorptiometry. Results Individuals with higher visceral fat mass and volume had significantly thicker cortex in the right posterior cingulate gyrus (β = 0.29 [p =.019] and β = 0.31 [p =.011], respectively), controlling for age, systolic blood pressure, total cholesterol level, and blood glucose level. Conclusions Visceral fat was significantly associated with thicker cortex in the posterior cingulate gyrus. Although future studies are necessary, these results indicate that central adiposity is associated with significant metabolic changes that impinge upon the central nervous system in middle age.

Idioma originalEnglish (US)
Páginas (desde-hasta)671-678
Número de páginas8
PublicaciónPsychosomatic Medicine
EstadoPublished - jul 13 2015
Publicado de forma externa

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Applied Psychology


Profundice en los temas de investigación de 'Central Adiposity and Cortical Thickness in Midlife'. En conjunto forman una huella única.

Citar esto