CENP-A ubiquitylation contributes to maintaining the chromosomal location of the centromere

Yohei Niikura; Risa Kitagawa; Katsumi Kitagawa

doi:10.3390/molecules24030402

CENP-A ubiquitylation contributes to maintaining the chromosomal location of the centromere

Yohei Niikura
, Risa Kitagawa
, Katsumi Kitagawa

Producción científica: Article › revisión exhaustiva

11 Citas (Scopus)

Resumen

The centromere plays an essential role in accurate chromosome segregation, and the chromosomal location of the centromere is determined by the presence of a histone H3 variant, centromere protein A (CENP-A), in centromeric nucleosomes. However, the precise mechanisms of deposition, maintenance, and inheritance of CENP-A at centromeres are unclear. We have reported that CENP-A deposition requires ubiquitylation of CENP-A lysine 124 mediated by the E3 ligase activity of Cullin 4A (CUL4A)—RING-box protein 1 (RBX1)—COP9 signalsome complex subunit 8 (COPS8). We have proposed a model of inheritance for CENP-A ubiquitylation, through dimerization between rounds of cell divisions, that maintains the position of centromeres.

Idioma original	English (US)
Número de artículo	402
Publicación	Molecules
Volumen	24
N.º	3
DOI	https://doi.org/10.3390/molecules24030402
Estado	Published - ene 22 2019

ASJC Scopus subject areas

Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry

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title = "CENP-A ubiquitylation contributes to maintaining the chromosomal location of the centromere",

abstract = "The centromere plays an essential role in accurate chromosome segregation, and the chromosomal location of the centromere is determined by the presence of a histone H3 variant, centromere protein A (CENP-A), in centromeric nucleosomes. However, the precise mechanisms of deposition, maintenance, and inheritance of CENP-A at centromeres are unclear. We have reported that CENP-A deposition requires ubiquitylation of CENP-A lysine 124 mediated by the E3 ligase activity of Cullin 4A (CUL4A)—RING-box protein 1 (RBX1)—COP9 signalsome complex subunit 8 (COPS8). We have proposed a model of inheritance for CENP-A ubiquitylation, through dimerization between rounds of cell divisions, that maintains the position of centromeres.",

keywords = "CENP-A, CUL4A-RBX1- COPS8 E3 ligase, Centromere, Centromere identity, Dimerization, Epigenetics, Kinetochore, Lysine 124 (K124), neocentromere, Ubiquitylation",

author = "Yohei Niikura and Risa Kitagawa and Katsumi Kitagawa",

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doi = "10.3390/molecules24030402",

language = "English (US)",

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T1 - CENP-A ubiquitylation contributes to maintaining the chromosomal location of the centromere

AU - Niikura, Yohei

AU - Kitagawa, Risa

AU - Kitagawa, Katsumi

PY - 2019/1/22

Y1 - 2019/1/22

N2 - The centromere plays an essential role in accurate chromosome segregation, and the chromosomal location of the centromere is determined by the presence of a histone H3 variant, centromere protein A (CENP-A), in centromeric nucleosomes. However, the precise mechanisms of deposition, maintenance, and inheritance of CENP-A at centromeres are unclear. We have reported that CENP-A deposition requires ubiquitylation of CENP-A lysine 124 mediated by the E3 ligase activity of Cullin 4A (CUL4A)—RING-box protein 1 (RBX1)—COP9 signalsome complex subunit 8 (COPS8). We have proposed a model of inheritance for CENP-A ubiquitylation, through dimerization between rounds of cell divisions, that maintains the position of centromeres.

AB - The centromere plays an essential role in accurate chromosome segregation, and the chromosomal location of the centromere is determined by the presence of a histone H3 variant, centromere protein A (CENP-A), in centromeric nucleosomes. However, the precise mechanisms of deposition, maintenance, and inheritance of CENP-A at centromeres are unclear. We have reported that CENP-A deposition requires ubiquitylation of CENP-A lysine 124 mediated by the E3 ligase activity of Cullin 4A (CUL4A)—RING-box protein 1 (RBX1)—COP9 signalsome complex subunit 8 (COPS8). We have proposed a model of inheritance for CENP-A ubiquitylation, through dimerization between rounds of cell divisions, that maintains the position of centromeres.

KW - CENP-A

KW - CUL4A-RBX1- COPS8 E3 ligase

KW - Centromere

KW - Centromere identity

KW - Dimerization

KW - Epigenetics

KW - Kinetochore

KW - Lysine 124 (K124), neocentromere

KW - Ubiquitylation

UR - https://www.scopus.com/pages/publications/85060515006

UR - https://www.scopus.com/pages/publications/85060515006#tab=citedBy

U2 - 10.3390/molecules24030402

DO - 10.3390/molecules24030402

M3 - Article

C2 - 30678315

AN - SCOPUS:85060515006

SN - 1420-3049

VL - 24

JO - Molecules

JF - Molecules

IS - 3

M1 - 402

ER -

CENP-A ubiquitylation contributes to maintaining the chromosomal location of the centromere

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