@inproceedings{eb322aaf5b2f408abbff4506f485726b,
title = "Cellular refractive index comparison of various prostate cancer and noncancerous cell lines via photonic-crystal biosensor",
abstract = "The current clinical standard for mass screening of prostate cancer are prostate-specific antigen (PSA) biomarker assays. Unfortunately, the low specificity of PSA's bioassays to prostate cancer leads to high false-positive rates, as such there is an urgent need for the development of a more specific detection system independent of PSA levels. In our previous research, we have successfully demonstrated, with the use of our Photonic-Crystal based biosensor in a Total-Internal-Reflection (PC-TIR) configuration, detection of prostate cancer (PC-3) cells against benign prostate hyperplasia (BPH-1) cells. The PC-TIR biosensor achieved detection of individual prostate cancer cells utilizing cellular refractive index (RI) as the only contrast parameter. To further study this methodology in vitro, we report a comprehensive study of the cellular RI's of various prostate cancer and noncancerous cell lines (i.e. RWPE-1, BPH-1, PC-3, DU-145, and LNCaP) via reflectance spectroscopy and single-cell RI imaging utilizing the PC-TIR biosensor. Our study shows promising clinical potential in utilizing the PC-TIR biosensor system for the detection of prostate cancer against noncancerous prostate epithelial cells.",
keywords = "Cancer Diagnostics, Cellular Refractive Index, Label-Free Imaging, Optical Biosensors, Photonic-Crystal Biosensor, Prostate Cancer",
author = "Frank Deluna and Melissa Cadena and Bingzhi Wang and Sun, \{Lu Zhe\} and Ye, \{Jing Yong\}",
note = "Publisher Copyright: {\textcopyright} 2019 SPIE.; Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XVII 2019 ; Conference date: 04-02-2019 Through 06-02-2019",
year = "2019",
doi = "10.1117/12.2507505",
language = "English (US)",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Leary, \{James F.\} and Attila Tarnok and Farkas, \{Daniel L.\}",
booktitle = "Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XVII",
}