CCL3L1 and CCR5 influence cell-mediated immunity and affect HIV-AIDS pathogenesis via viral entry-independent mechanisms

Matthew J. Dolan; Hemant Kulkarni; Jose F. Camargo; Weijing He; Alison Smith; Juan Manuel Anaya; Toshiyuki Miura; Frederick M. Hecht; Manju Mamtani; Florencia Pereyra; Vincent Marconi; Andrea Mangano; Luisa Sen; Rosa Bologna; Robert A. Clark; Stephanie A. Anderson; Judith Delmar; Robert J. O'Connell; Andrew Lloyd; Jeffrey Martin; Seema S. Ahuja; Brian K. Agan; Bruce D. Walker; Steven G. Deeks; Sunil K. Ahuja

doi:10.1038/ni1521

CCL3L1 and CCR5 influence cell-mediated immunity and affect HIV-AIDS pathogenesis via viral entry-independent mechanisms

Matthew J. Dolan, Hemant Kulkarni, Jose F. Camargo, Weijing He, Alison Smith, Juan Manuel Anaya, Toshiyuki Miura, Frederick M. Hecht, Manju Mamtani, Florencia Pereyra, Vincent Marconi, Andrea Mangano, Luisa Sen, Rosa Bologna, Robert A. Clark, Stephanie A. Anderson, Judith Delmar, Robert J. O'Connell, Andrew Lloyd, Jeffrey MartinSeema S. Ahuja, Brian K. Agan, Bruce D. Walker, Steven G. Deeks, Sunil K. Ahuja

Producción científica: Article › revisión exhaustiva

151 Citas (Scopus)

Resumen

Although host defense against human immunodeficiency virus 1 (HIV-1) relies mainly on cell-mediated immunity (CMI), the determinants of CMI in humans are poorly understood. Here we demonstrate that variations in the genes encoding the chemokine CCL3L1 and HIV coreceptor CCR5 influence CMI in both healthy and HIV-infected individuals. CCL3L1-CCR5 genotypes associated with altered CMI in healthy subjects were similar to those that influence the risk of HIV transmission, viral burden and disease progression. However, CCL3L1-CCR5 genotypes also modify HIV clinical course independently of their effects on viral load and CMI. These results identify CCL3L1 and CCR5 as major determinants of CMI and demonstrate that these host factors influence HIV pathogenesis through their effects on both CMI and other viral entry-independent mechanisms.

Idioma original	English (US)
Páginas (desde-hasta)	1324-1336
Número de páginas	13
Publicación	Nature Immunology
Volumen	8
N.º	12
DOI	https://doi.org/10.1038/ni1521
Estado	Published - dic 2007

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1038/ni1521

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Dolan, M. J., Kulkarni, H., Camargo, J. F., He, W., Smith, A., Anaya, J. M., Miura, T., Hecht, F. M., Mamtani, M., Pereyra, F., Marconi, V., Mangano, A., Sen, L., Bologna, R., Clark, R. A., Anderson, S. A., Delmar, J., O'Connell, R. J., Lloyd, A., ... Ahuja, S. K. (2007). CCL3L1 and CCR5 influence cell-mediated immunity and affect HIV-AIDS pathogenesis via viral entry-independent mechanisms. Nature Immunology, 8(12), 1324-1336. https://doi.org/10.1038/ni1521

Dolan, MJ, Kulkarni, H, Camargo, JF, He, W, Smith, A, Anaya, JM, Miura, T, Hecht, FM, Mamtani, M, Pereyra, F, Marconi, V, Mangano, A, Sen, L, Bologna, R, Clark, RA, Anderson, SA, Delmar, J, O'Connell, RJ, Lloyd, A, Martin, J, Ahuja, SS, Agan, BK, Walker, BD, Deeks, SG & Ahuja, SK 2007, 'CCL3L1 and CCR5 influence cell-mediated immunity and affect HIV-AIDS pathogenesis via viral entry-independent mechanisms', Nature Immunology, vol. 8, n.º 12, pp. 1324-1336. https://doi.org/10.1038/ni1521

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title = "CCL3L1 and CCR5 influence cell-mediated immunity and affect HIV-AIDS pathogenesis via viral entry-independent mechanisms",

abstract = "Although host defense against human immunodeficiency virus 1 (HIV-1) relies mainly on cell-mediated immunity (CMI), the determinants of CMI in humans are poorly understood. Here we demonstrate that variations in the genes encoding the chemokine CCL3L1 and HIV coreceptor CCR5 influence CMI in both healthy and HIV-infected individuals. CCL3L1-CCR5 genotypes associated with altered CMI in healthy subjects were similar to those that influence the risk of HIV transmission, viral burden and disease progression. However, CCL3L1-CCR5 genotypes also modify HIV clinical course independently of their effects on viral load and CMI. These results identify CCL3L1 and CCR5 as major determinants of CMI and demonstrate that these host factors influence HIV pathogenesis through their effects on both CMI and other viral entry-independent mechanisms.",

author = "Dolan, {Matthew J.} and Hemant Kulkarni and Camargo, {Jose F.} and Weijing He and Alison Smith and Anaya, {Juan Manuel} and Toshiyuki Miura and Hecht, {Frederick M.} and Manju Mamtani and Florencia Pereyra and Vincent Marconi and Andrea Mangano and Luisa Sen and Rosa Bologna and Clark, {Robert A.} and Anderson, {Stephanie A.} and Judith Delmar and O'Connell, {Robert J.} and Andrew Lloyd and Jeffrey Martin and Ahuja, {Seema S.} and Agan, {Brian K.} and Walker, {Bruce D.} and Deeks, {Steven G.} and Ahuja, {Sunil K.}",

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AU - Dolan, Matthew J.

AU - Kulkarni, Hemant

AU - Camargo, Jose F.

AU - He, Weijing

AU - Smith, Alison

AU - Anaya, Juan Manuel

AU - Miura, Toshiyuki

AU - Hecht, Frederick M.

AU - Mamtani, Manju

AU - Pereyra, Florencia

AU - Marconi, Vincent

AU - Mangano, Andrea

AU - Sen, Luisa

AU - Bologna, Rosa

AU - Clark, Robert A.

AU - Anderson, Stephanie A.

AU - Delmar, Judith

AU - O'Connell, Robert J.

AU - Lloyd, Andrew

AU - Martin, Jeffrey

AU - Ahuja, Seema S.

AU - Agan, Brian K.

AU - Walker, Bruce D.

AU - Deeks, Steven G.

AU - Ahuja, Sunil K.

PY - 2007/12

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AB - Although host defense against human immunodeficiency virus 1 (HIV-1) relies mainly on cell-mediated immunity (CMI), the determinants of CMI in humans are poorly understood. Here we demonstrate that variations in the genes encoding the chemokine CCL3L1 and HIV coreceptor CCR5 influence CMI in both healthy and HIV-infected individuals. CCL3L1-CCR5 genotypes associated with altered CMI in healthy subjects were similar to those that influence the risk of HIV transmission, viral burden and disease progression. However, CCL3L1-CCR5 genotypes also modify HIV clinical course independently of their effects on viral load and CMI. These results identify CCL3L1 and CCR5 as major determinants of CMI and demonstrate that these host factors influence HIV pathogenesis through their effects on both CMI and other viral entry-independent mechanisms.

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CCL3L1 and CCR5 influence cell-mediated immunity and affect HIV-AIDS pathogenesis via viral entry-independent mechanisms

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