@article{613a0614a82e401d9009028ee3b6f4f1,
title = "Cause or casualty: The role of mitochondrial DNA in aging and age-associated disease",
abstract = "The mitochondrial genome (mtDNA) represents a tiny fraction of the whole genome, comprising just 16.6 kilobases encoding 37 genes involved in oxidative phosphorylation and the mitochondrial translation machinery. Despite its small size, much interest has developed in recent years regarding the role of mtDNA as a determinant of both aging and age-associated diseases. A number of studies have presented compelling evidence for key roles of mtDNA in age-related pathology, although many are correlative rather than demonstrating cause. In this review we will evaluate the evidence supporting and opposing a role for mtDNA in age-associated functional declines and diseases. We provide an overview of mtDNA biology, damage and repair as well as the influence of mitochondrial haplogroups, epigenetics and maternal inheritance in aging and longevity.",
keywords = "Aging, Lifespan, Mitochondria, mtDNA",
author = "Chocron, {E. Sandra} and Erin Munk{\'a}csy and Pickering, {Andrew M.}",
note = "Funding Information: This research was supported by a Voelcker Foundation Young Investigator Award , the 2018 Glenn Foundation for Medical Research, the AFAR Grant for Junior Faculty program , the NIH R56 AG061051 Grant and the UTHSCSA Nathan Shock Pilots grants program to AMP. Additional support was provided through a National Institute of Health (NIH) T32 postdoctoral training grant [ AG021890-14 ] to EM. Funding Information: This research was supported by a Voelcker Foundation Young Investigator Award, the 2018 Glenn Foundation for Medical Research, the AFAR Grant for Junior Faculty program, the NIH R56 AG061051 Grant and the UTHSCSA Nathan Shock Pilots grants program to AMP. Additional support was provided through a National Institute of Health (NIH) T32 postdoctoral training grant [AG021890-14] to EM. Publisher Copyright: {\textcopyright} 2018 Elsevier B.V.",
year = "2019",
month = feb,
day = "1",
doi = "10.1016/j.bbadis.2018.09.035",
language = "English (US)",
volume = "1865",
pages = "285--297",
journal = "Biochimica et Biophysica Acta - Molecular Basis of Disease",
issn = "0925-4439",
publisher = "Elsevier",
number = "2",
}