TY - JOUR
T1 - Cardioprotective Role of Melatonin in Acute Myocardial Infarction
AU - Fu, Zhenhong
AU - Jiao, Yang
AU - Wang, Jihang
AU - Zhang, Ying
AU - Shen, Mingzhi
AU - Reiter, Russel J.
AU - Xi, Qing
AU - Chen, Yundai
N1 - Funding Information:
by National Natural Science (fund numbers 81500269,
Funding Information:
Funding. This study was supported by National Natural Science Foundation of China (fund numbers 81500269, 81500202, and 81570383).
Funding Information:
This study was supported Foundation of China 81500202, and 81570383).
Publisher Copyright:
© Copyright © 2020 Fu, Jiao, Wang, Zhang, Shen, Reiter, Xi and Chen.
PY - 2020/4/29
Y1 - 2020/4/29
N2 - Melatonin is a pleiotropic, indole secreted, and synthesized by the human pineal gland. Melatonin has biological effects including anti-apoptosis, protecting mitochondria, anti-oxidation, anti-inflammation, and stimulating target cells to secrete cytokines. Its protective effect on cardiomyocytes in acute myocardial infarction (AMI) has caused widespread interest in the actions of this molecule. The effects of melatonin against oxidative stress, promoting autophagic repair of cells, regulating immune and inflammatory responses, enhancing mitochondrial function, and relieving endoplasmic reticulum stress, play crucial roles in protecting cardiomyocytes from infarction. Mitochondrial apoptosis and dysfunction are common occurrence in cardiomyocyte injury after myocardial infarction. This review focuses on the targets of melatonin in protecting cardiomyocytes in AMI, the main molecular signaling pathways that melatonin influences in its endogenous protective role in myocardial infarction, and the developmental prospect of melatonin in myocardial infarction treatment.
AB - Melatonin is a pleiotropic, indole secreted, and synthesized by the human pineal gland. Melatonin has biological effects including anti-apoptosis, protecting mitochondria, anti-oxidation, anti-inflammation, and stimulating target cells to secrete cytokines. Its protective effect on cardiomyocytes in acute myocardial infarction (AMI) has caused widespread interest in the actions of this molecule. The effects of melatonin against oxidative stress, promoting autophagic repair of cells, regulating immune and inflammatory responses, enhancing mitochondrial function, and relieving endoplasmic reticulum stress, play crucial roles in protecting cardiomyocytes from infarction. Mitochondrial apoptosis and dysfunction are common occurrence in cardiomyocyte injury after myocardial infarction. This review focuses on the targets of melatonin in protecting cardiomyocytes in AMI, the main molecular signaling pathways that melatonin influences in its endogenous protective role in myocardial infarction, and the developmental prospect of melatonin in myocardial infarction treatment.
KW - cardiomyocyte
KW - cardioprotective
KW - melatonin
KW - mitochondrion
KW - myocardial infarction
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U2 - 10.3389/fphys.2020.00366
DO - 10.3389/fphys.2020.00366
M3 - Review article
C2 - 32411013
AN - SCOPUS:85084669298
SN - 1664-042X
VL - 11
JO - Frontiers in Physiology
JF - Frontiers in Physiology
M1 - 366
ER -