Cardiac MRI shows an association of lower cardiorespiratory fitness with decreased myocardial mass and higher cardiac stiffness in the general population – The Sedentary's Heart

Marcello Ricardo Paulista Markus, Till Ittermann, Christine Julia Drzyzga, Martin Bahls, Sabine Schipf, Ulrike Siewert-Markus, Sebastian Edgar Baumeister, Paul Schumacher, Ralf Ewert, Henry Völzke, Elisabeth Steinhagen-Thiessen, Robin Bülow, Heribert Schunkert, Ramachandran S. Vasan, Stephan Burkhard Felix, Marcus Dörr

Resultado de la investigación: Articlerevisión exhaustiva

3 Citas (Scopus)

Resumen

Background: The heart has the capacity to adapt to different demands. The pathophysiological mechanisms involved with sedentarism are not fundamentally the opposite of those related with physical activity and regular exercise. We investigated the impact of lower cardiorespiratory fitness (CRF) on heart's plasticity and function in a population-based setting. Methods: We used data from 1165 participants (539 women; 46.3%) aged 21–81 years from two independent cohorts of the Study of Health in Pomerania (SHIP-2 and SHIP-TREND-0). We analyzed the cross-sectional associations of peak oxygen uptake (VO2peak), determined by symptom-limited cardiopulmonary exercise testing, with structural and functional left ventricular (LV) and left atrial (LA) parameters determined by magnetic resonance imaging (MRI) using multivariable- adjusted linear regression models. Results: A 1 L/min lower VO2peak was associated with a 10.5 g (95% confidence interval: 8.00 to 12.9; p < 0.001) lower LV mass, a 14.8 mL (10.9 to 18.6; p < 0.001) lower LV end-diastolic volume, a 0.29 mm (0.19 to 0.40; p < 0.001) lower LV wall-thickness, a 8.85 mL/beat (6.53 to 11.2; p < 0.001) lower LV stroke volume, a 0.42 L/min (0.25 to 0.60; p < 0.001) lower LV cardiac output and a 7.51 mL (3.88 to 11.1; p < 0.001) lower LA end-diastolic volume. Moreover, there were no associations with a concentric or eccentric remodeling and LV and LA ejection fraction. Conclusions: Lower CRF was associated with a smaller heart, LV wall-thickness and mass, LV and LA stroke volume and cardiac output. Conversely, there was no association with LA and LV ejection fraction. Our cross-sectional observations are consistent with cardiac adaptations reflecting reduced volume loading demands of a sedentary lifestyle – “the sedentary's heart”.

Idioma originalEnglish (US)
Páginas (desde-hasta)25-35
Número de páginas11
PublicaciónProgress in Cardiovascular Diseases
Volumen68
DOI
EstadoPublished - sept. 1 2021
Publicado de forma externa

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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