Cancer omics: From regulatory networks to clinical outcomes

Binhua Tang, Pei Yin Hsu, Tim H.M. Huang, Victor X. Jin

Producción científica: Review articlerevisión exhaustiva

9 Citas (Scopus)

Resumen

Current limitation in cancer genomic studies is a lack of the integration of various omics data generated through next generation sequencing technologies, as well as a lack of the sounding and comprehensive epigenomic and genomic information about a particular cancer cell type. In this review, we will discuss main aspects of current genomics research with its application in cancer topics. We will first overview the next-generation sequencing technologies, then outline the major computational approaches, particularly focusing on ChIP-based omics data, and list several remaining open questions facing computational biologists, further present regulatory network analysis inferred from the ChIP-based omics data; finally implicate the clinical outcomes from the network and pathway analysis.

Idioma originalEnglish (US)
Páginas (desde-hasta)277-283
Número de páginas7
PublicaciónCancer Letters
Volumen340
N.º2
DOI
EstadoPublished - nov 1 2013

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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