Cancer mutation signatures, DNA damage mechanisms, and potential clinical implications

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36 Citas (Scopus)

Resumen

Knowledge of cancer genomic DNA sequences has created unprecedented opportunities for mutation studies. Computational analyses have begun to decipher mutational signatures that identify underlying causes. A recent analysis encompassing 30 cancer types reported 20 distinct mutation signatures, resulting from ultraviolet light, deficiencies in DNA replication and repair, and unexpectedly large contributions from both spontaneous and APOBEC-catalyzed DNA cytosine deamination. Mutational signatures have the potential to become diagnostic, prognostic, and therapeutic biomarkers as well as factors in therapy development.

Idioma originalEnglish (US)
Número de artículo87
PublicaciónGenome Medicine
Volumen5
N.º9
DOI
EstadoPublished - sept 27 2013
Publicado de forma externa

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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