Resumen
Ca2+ is one of the key regulators of cell survival, but Ca2+ can also induce apoptosis in response to a variety of pathological conditions. The pro-apoptotic effects of Ca2+ are mediated by a diverse range of Ca2+-sensitive factors that are compartmentalized in various intracellular organelles including the ER, cytoplasm, and mitochondria. The Ca2+ dynamics of these organelles appear to be modulated by the apoptosis-regulating Bcl-2 family proteins. In this paper, the recent progress of research on the mechanisms mediating the apoptosis-regulating effects of Ca2+ and the interactions of Bcl-2 family proteins with the Ca2+ storage organelles are discussed.
Idioma original | English (US) |
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Páginas (desde-hasta) | 445-454 |
Número de páginas | 10 |
Publicación | Biochemical and Biophysical Research Communications |
Volumen | 304 |
N.º | 3 |
DOI | |
Estado | Published - may 9 2003 |
Publicado de forma externa | Sí |
ASJC Scopus subject areas
- Molecular Biology
- Biophysics
- Biochemistry
- Cell Biology