Calcium signaling and apoptosis

György Hajnóczky, Erika Davies, Muniswamy Madesh

Producción científica: Articlerevisión exhaustiva

414 Citas (Scopus)

Resumen

Ca2+ is one of the key regulators of cell survival, but Ca2+ can also induce apoptosis in response to a variety of pathological conditions. The pro-apoptotic effects of Ca2+ are mediated by a diverse range of Ca2+-sensitive factors that are compartmentalized in various intracellular organelles including the ER, cytoplasm, and mitochondria. The Ca2+ dynamics of these organelles appear to be modulated by the apoptosis-regulating Bcl-2 family proteins. In this paper, the recent progress of research on the mechanisms mediating the apoptosis-regulating effects of Ca2+ and the interactions of Bcl-2 family proteins with the Ca2+ storage organelles are discussed.

Idioma originalEnglish (US)
Páginas (desde-hasta)445-454
Número de páginas10
PublicaciónBiochemical and Biophysical Research Communications
Volumen304
N.º3
DOI
EstadoPublished - may 9 2003
Publicado de forma externa

ASJC Scopus subject areas

  • Molecular Biology
  • Biophysics
  • Biochemistry
  • Cell Biology

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