BRCA1, hormone, and tissue-specific tumor suppression

Yanfen Hu

doi:10.7150/ijbs.5.20

BRCA1, hormone, and tissue-specific tumor suppression

Yanfen Hu

Department of Molecular Medicine

Resultado de la investigación: Review article › revisión exhaustiva

27 Citas (Scopus)

Resumen

Germline mutations of BRCA1 predispose women to breast and ovarian cancers. Elucidating molecular mechanism of tissue- and gender-specific phenomena in BRCA1-related tumors is a key to our understanding of BRCA1 function in tumor suppression. This review summarizes studies in recent years on the link between BRCA1 and estrogen/progesterone signaling pathways, as well as discusses various models underscoring a triangle relationship among BRCA1, estrogen and genome instability.

Idioma original	English (US)
Páginas (desde-hasta)	20-27
Número de páginas	8
Publicación	International Journal of Biological Sciences
Volumen	5
N.º	1
DOI	https://doi.org/10.7150/ijbs.5.20
Estado	Published - 2009

ASJC Scopus subject areas

Ecology, Evolution, Behavior and Systematics
Applied Microbiology and Biotechnology
Molecular Biology
Developmental Biology
Cell Biology

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KW - Genome instability

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BRCA1, hormone, and tissue-specific tumor suppression

Resumen

ASJC Scopus subject areas

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Huella

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