Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion

Naohiro Terada, Takashi Hamazaki, Masahiro Oka, Masanori Hoki, Diana M. Mastalerz, Yuka Nakano, Edwin M. Meyer, Laurence Morel, Bryon E. Petersen, Edward W. Scott

Resultado de la investigación: Articlerevisión exhaustiva

1772 Citas (Scopus)

Resumen

Recent studies have demonstrated that transplanted bone marrow cells can turn into unexpected lineages including myocytes, hepatocytes, neurons and many others. A potential problem, however, is that reports discussing such 'transdifferentiation' in vivo tend to conclude donor origin of transdifferentiated cells on the basis of the existence of donor-specific genes such as Y-chromosome markers. Here we demonstrate that mouse bone marrow cells can fuse spontaneously with embryonic stem cells in culture in vitro that contains interleukin-3. Moreover, spontaneously fused bone marrow cells can subsequently adopt the phenotype of the recipient cells, which, without detailed genetic analysis, might be interpreted as 'dedifferentiation' or transdifferentiation.

Idioma originalEnglish (US)
Páginas (desde-hasta)542-545
Número de páginas4
PublicaciónNature
Volumen416
N.º6880
DOI
EstadoPublished - abr. 4 2002
Publicado de forma externa

ASJC Scopus subject areas

  • General

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