Bisphosphonates in the adjuvant treatment of cancer: Experimental evidence and first clinical results

I. J. Diel, G. R. Mundy

Resultado de la investigación: Review articlerevisión exhaustiva

27 Citas (Scopus)

Resumen

Several animal models, as well as a number of cell culture experiments, indicate a prophylactic effect of bisphosphonates in respect of subsequent bone metastasis. Moreover, in preliminary clinical trials involving patients with advanced breast cancer and local or remote metastases, biophosphonates produced a reduction in new skeletal metastases. This overview summarizes and discusses the results of the latest investigations. It opens with a section on the pathophysiology of bone metastasis, which is followed by a report on animal models and first studies of bisphosphonate treatment as a new approach in systemic adjuvant therapy. (C) 2000 Cancer Research Campaign.

Idioma originalEnglish (US)
Páginas (desde-hasta)1381-1386
Número de páginas6
PublicaciónBritish Journal of Cancer
Volumen82
N.º8
DOI
EstadoPublished - 2000
Publicado de forma externa

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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