@article{7c6db9d5940e4680a8efb4231e753eb5,
title = "Bisphosphonates in the adjuvant treatment of cancer: Experimental evidence and first clinical results",
abstract = "Several animal models, as well as a number of cell culture experiments, indicate a prophylactic effect of bisphosphonates in respect of subsequent bone metastasis. Moreover, in preliminary clinical trials involving patients with advanced breast cancer and local or remote metastases, biophosphonates produced a reduction in new skeletal metastases. This overview summarizes and discusses the results of the latest investigations. It opens with a section on the pathophysiology of bone metastasis, which is followed by a report on animal models and first studies of bisphosphonate treatment as a new approach in systemic adjuvant therapy. (C) 2000 Cancer Research Campaign.",
keywords = "Bisphosphonates, Bone metastases, Prevention, Prophylaxis",
author = "Diel, {I. J.} and Mundy, {G. R.}",
note = "Funding Information: IBCG: R Bartl, Ludwig-Maximilians Universit{\"a}t, Klinikum Grosshadern, Germany; JJ Body, Institut J Bordet, Universit{\'e} Libre de Bruxelles, Belgium; P Burckhardt, CHUV University Hospital, Lausanne, Switzerland; PD Delmas, INSERM Unit{\'e} 403, H{\^o}pital Edouard Herriot, Universit{\'e} Lyon, France; IJ Diel, Department of Ob/Gyn, University of Heidelberg, Germany; I Elomaa, Department of Radiotherapy and Oncology, University of Helsinki, Finland; D Felsenberg, Osteoporosis Research Group, Klinikum Steglitz, Berlin, Germany; H Fleisch, Effingerstr 40, Berne, Switzerland; JA Kanis, University of Sheffield, Metabolic Bone Unit, Medical School, Sheffield, UK; RA Kyle, Mayo Clinic, Rochester, MN, USA; GR Mundy, University of Texas, Health Science Center, San Antonio, USA; AHG Paterson, Tom Baker Cancer Center, Calgary, Canada; M Pecherstorfer, Wilhelminenspital, Wien, Austria; RD Rubens, Guys Hospital, London, UK. The International Bone and Cancer Study Group is supported in part by a grant from Roche Pharmaceuticals, Basel, Switzerland.",
year = "2000",
doi = "10.1054/bjoc.1999.1077",
language = "English (US)",
volume = "82",
pages = "1381--1386",
journal = "British Journal of Cancer",
issn = "0007-0920",
publisher = "Nature Publishing Group",
number = "8",
}