TY - JOUR
T1 - Biomarkers for bipolar disorder
T2 - current status and challenges ahead
AU - Teixeira, Antonio L.
AU - Colpo, Gabriela D.
AU - Fries, Gabriel R.
AU - Bauer, Isabelle E.
AU - Selvaraj, Sudhakar
N1 - Publisher Copyright:
© 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2019/1/2
Y1 - 2019/1/2
N2 - Introduction: Bipolar disorder (BD) is a chronic psychiatric disorder marked by clinical and pathophysiological heterogeneity. There is a high expectation that personalized approaches can improve the management of patients with BD. For that, identification and validation of potential biomarkers are fundamental. Areas covered: This manuscript will critically review the current status of different biomarkers for BD, including peripheral, genetic, neuroimaging, and neurophysiological candidates, discussing the challenges to move the field forward. Expert commentary: There are no lab or complementary tests currently recommended for the diagnosis or management of patients with BD. Panels composed by multiple biomarkers will probably contribute to stratifying patients according to their clinical stage, therapeutic response, and prognosis.
AB - Introduction: Bipolar disorder (BD) is a chronic psychiatric disorder marked by clinical and pathophysiological heterogeneity. There is a high expectation that personalized approaches can improve the management of patients with BD. For that, identification and validation of potential biomarkers are fundamental. Areas covered: This manuscript will critically review the current status of different biomarkers for BD, including peripheral, genetic, neuroimaging, and neurophysiological candidates, discussing the challenges to move the field forward. Expert commentary: There are no lab or complementary tests currently recommended for the diagnosis or management of patients with BD. Panels composed by multiple biomarkers will probably contribute to stratifying patients according to their clinical stage, therapeutic response, and prognosis.
KW - biomarkers
KW - Bipolar disorder
KW - genetics
KW - inflammation markers
KW - neuroimaging
KW - neurophysiological markers
KW - oxidative stress markers
KW - personalized psychiatry
UR - http://www.scopus.com/inward/record.url?scp=85059236324&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85059236324&partnerID=8YFLogxK
U2 - 10.1080/14737175.2019.1550361
DO - 10.1080/14737175.2019.1550361
M3 - Review article
C2 - 30451546
AN - SCOPUS:85059236324
SN - 1473-7175
VL - 19
SP - 67
EP - 81
JO - Expert Review of Neurotherapeutics
JF - Expert Review of Neurotherapeutics
IS - 1
ER -