TY - GEN
T1 - Bayesian non-negative factor analysis for reconstructing transcriptional regulatory network
AU - Meng, Jia
AU - Zhang, Jianqiu
AU - Chen, Yidong
AU - Huang, Yufei
PY - 2011
Y1 - 2011
N2 - Transcriptional regulation by transcription factors (TFs) controls when and how much RNA is created. Due to technical limitations, the protein level expressions of TFs are usually unknown, making computational reconstruction of transcriptional network a difficult task. We proposed here a novel Bayesian non-negative factor approach, which is capable to estimate both the non-negative abundances of the transcription factors, their regulatory effects, and sample clustering information by integrating microarray data and existing knowledge regarding TFs regulated target genes. The results demonstrated its validity and effectiveness to reconstructing transcriptional networks by transcription factors through simulated systems and real data.
AB - Transcriptional regulation by transcription factors (TFs) controls when and how much RNA is created. Due to technical limitations, the protein level expressions of TFs are usually unknown, making computational reconstruction of transcriptional network a difficult task. We proposed here a novel Bayesian non-negative factor approach, which is capable to estimate both the non-negative abundances of the transcription factors, their regulatory effects, and sample clustering information by integrating microarray data and existing knowledge regarding TFs regulated target genes. The results demonstrated its validity and effectiveness to reconstructing transcriptional networks by transcription factors through simulated systems and real data.
KW - Bayesian factor analysis
KW - PCA
KW - non-negative factor analysis
KW - principle component analysis
UR - http://www.scopus.com/inward/record.url?scp=80052186997&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80052186997&partnerID=8YFLogxK
U2 - 10.1109/SSP.2011.5967704
DO - 10.1109/SSP.2011.5967704
M3 - Conference contribution
AN - SCOPUS:80052186997
SN - 9781457705700
T3 - IEEE Workshop on Statistical Signal Processing Proceedings
SP - 361
EP - 364
BT - 2011 IEEE Statistical Signal Processing Workshop, SSP 2011
T2 - 2011 IEEE Statistical Signal Processing Workshop, SSP 2011
Y2 - 28 June 2011 through 30 June 2011
ER -