Baculovirus regulation of apoptosis

Lois K. Miller, William J. Kaiser, Somasekar Seshagiri

Resultado de la investigación: Articlerevisión exhaustiva

3 Citas (Scopus)


The baculovirus AcMNPV induces apoptosis in a host-specific manner which involves the activation of host caspases (cysteine-dependent, aspartate-specific proteases). AcMNPV carries a novel gene, p35, which encodes a stoichiometric inhibitor of active caspases, thereby blocking apoptosis. P35 is cleaved by caspases and the cleavage products form a stable complex with the caspase. Baculoviruses also carry genes known as iaps (inhibitors of apoptosis), some of which can actively suppress apoptosis by inhibiting the activation of caspases. Members of the IAP family are found in both viral and animal genomes and interact physically with a variety of proteins associated with apoptotic pathways including Reaper, Doom, TRAF2, and some caspases. The ability of baculoviruses to block apoptosis influences their pathogenicity and host range.

Idioma originalEnglish (US)
Páginas (desde-hasta)445-452
Número de páginas8
PublicaciónSeminars in Virology
EstadoPublished - ago 1998

ASJC Scopus subject areas

  • Immunology
  • Virology


Profundice en los temas de investigación de 'Baculovirus regulation of apoptosis'. En conjunto forman una huella única.

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