Automation to Enable High-Throughput Chemical Proteomics

Zongtao Lin, Joanna Gongora, Xingyu Liu, Yixuan Xie, Chenfeng Zhao, Dongwen Lv, Benjamin A. Garcia

Producción científica: Review articlerevisión exhaustiva

Resumen

Chemical proteomics utilizes small-molecule probes to covalently engage with their interacting proteins. Since chemical probes are tagged to the active or binding sites of functional proteins, chemical proteomics can be used to profile protein targets, reveal precise binding sites/mechanisms, and screen inhibitors competing with probes in a biological context. These capabilities of chemical proteomics have great potential to enable discoveries of both drug targets and lead compounds. However, chemical proteomics is limited by the time-consuming bottleneck of sample preparations, which are processed manually. With the advancement of robotics and artificial intelligence, it is now possible to automate workflows to make chemical proteomics sample preparation a high-throughput process. An automated robotic system represents a major technological opportunity to speed up advances in proteomics, open new frontiers in drug target discovery, and broaden the future of chemical biology.

Idioma originalEnglish (US)
Páginas (desde-hasta)3676-3682
Número de páginas7
PublicaciónJournal of Proteome Research
Volumen22
N.º12
DOI
EstadoPublished - dic 1 2023

ASJC Scopus subject areas

  • General Chemistry
  • Biochemistry

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