Atypical B cells consist of subsets with distinct functional profiles

Raphael A. Reyes, Gayani Batugedara, Paramita Dutta, Ashley B. Reers, Rolando Garza, Isaac Ssewanyana, Prasanna Jagannathan, Margaret E. Feeney, Bryan Greenhouse, Sebastiaan Bol, Ferhat Ay, Evelien M. Bunnik

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Atypical B cells are a population of activated B cells that are commonly enriched in individuals with chronic immune activation but are also part of a normal immune response to infection or vaccination. To better define the role of atypical B cells in the human adaptive immune response, we performed single-cell sequencing of transcriptomes, cell surface markers, and B cell receptors in individuals with chronic exposure to the malaria parasite Plasmodium falciparum, a condition known to lead to accumulation of circulating atypical B cells. We identified three previously uncharacterized populations of atypical B cells with distinct transcriptional and functional profiles and observed marked differences among these three subsets in their ability to produce immunoglobulin G upon T-cell-dependent activation. Our findings help explain the conflicting observations in prior studies regarding the function of atypical B cells and highlight their different roles in the adaptive immune response in chronic inflammatory conditions.

Idioma originalEnglish (US)
Número de artículo108496
EstadoPublished - dic 15 2023
Publicado de forma externa

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