TY - JOUR
T1 - Attenuation of the activity of caspofungin at high concentrations against Candida albicans
T2 - Possible role of cell wall integrity and calcineurin pathways
AU - Wiederhold, Nathan P.
AU - Kontoyiannis, Dimitrios P.
AU - Prince, Randall A.
AU - Lewis, Russell E.
PY - 2005/12
Y1 - 2005/12
N2 - Caspofungin had diminished activity in vitro against Candida albicans at concentrations of 8 to 32 μg/ml. This phenomenon was markedly attenuated in a Δmkc1/Δmkc1 deletion mutant and by the addition of cyclosporine to the wild type. Short exposure to these Caspofungin concentrations resulted in MKC1 upregulation, suggesting roles of cell wall integrity and calcineurin pathways.
AB - Caspofungin had diminished activity in vitro against Candida albicans at concentrations of 8 to 32 μg/ml. This phenomenon was markedly attenuated in a Δmkc1/Δmkc1 deletion mutant and by the addition of cyclosporine to the wild type. Short exposure to these Caspofungin concentrations resulted in MKC1 upregulation, suggesting roles of cell wall integrity and calcineurin pathways.
UR - https://www.scopus.com/pages/publications/28844490053
UR - https://www.scopus.com/inward/citedby.url?scp=28844490053&partnerID=8YFLogxK
U2 - 10.1128/AAC.49.12.5146-5148.2005
DO - 10.1128/AAC.49.12.5146-5148.2005
M3 - Article
C2 - 16304189
AN - SCOPUS:28844490053
SN - 0066-4804
VL - 49
SP - 5146
EP - 5148
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 12
ER -