Association study between late-onset Alzheimer's disease and the transferrin gene polymorphisms in Chinese

Peng Zhang; Ze Yang; Chuanfang Zhang; Zeping Lu; Xiaohong Shi; Weidong Zheng; Chunling Wan; Duanyang Zhang; Chenguang Zheng; Shu Li; Feng Jin; Li Wang

doi:10.1016/S0304-3940(03)00837-1

Association study between late-onset Alzheimer's disease and the transferrin gene polymorphisms in Chinese

Peng Zhang, Ze Yang, Chuanfang Zhang, Zeping Lu, Xiaohong Shi, Weidong Zheng, Chunling Wan, Duanyang Zhang, Chenguang Zheng, Shu Li, Feng Jin, Li Wang

Producción científica: Article › revisión exhaustiva

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Resumen

To investigate the possible involvement of the transferrin (TF) gene polymorphism in the manifestation of Alzheimer's disease (AD), we analyzed the TF and apolipoprotein E (APOE) genotypes of 67 sporadic late-onset AD patients and 131 normal elderly controls in the Chinese population. Our data showed that the TF C1 homozygosity carriers had an increased risk of AD in subjects ≥75 years of age, showing that homozygosity for the TF C1 allele was associated with an approximately three-fold increased risk (OR=3.57, 95% CI, 1.24-10.27, P=0.014). No synergic effects were found between the APOE ε4 allele and TF gene polymorphisms.

Idioma original	English (US)
Páginas (desde-hasta)	209-211
Número de páginas	3
Publicación	Neuroscience Letters
Volumen	349
N.º	3
DOI	https://doi.org/10.1016/S0304-3940(03)00837-1
Estado	Published - oct 9 2003
Publicado de forma externa	Sí

ASJC Scopus subject areas

General Neuroscience

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@article{34b2c8d8988b4179b7210a0cb9f20041,

title = "Association study between late-onset Alzheimer's disease and the transferrin gene polymorphisms in Chinese",

abstract = "To investigate the possible involvement of the transferrin (TF) gene polymorphism in the manifestation of Alzheimer's disease (AD), we analyzed the TF and apolipoprotein E (APOE) genotypes of 67 sporadic late-onset AD patients and 131 normal elderly controls in the Chinese population. Our data showed that the TF C1 homozygosity carriers had an increased risk of AD in subjects ≥75 years of age, showing that homozygosity for the TF C1 allele was associated with an approximately three-fold increased risk (OR=3.57, 95% CI, 1.24-10.27, P=0.014). No synergic effects were found between the APOE ε4 allele and TF gene polymorphisms.",

keywords = "Alzheimer's disease, Apolipoprotein E, Chinese, Gene polymorphisms, Transferrin",

author = "Peng Zhang and Ze Yang and Chuanfang Zhang and Zeping Lu and Xiaohong Shi and Weidong Zheng and Chunling Wan and Duanyang Zhang and Chenguang Zheng and Shu Li and Feng Jin and Li Wang",

note = "Funding Information: This work was supported by the National “863” Program (2002AA223031), the National “973” Program (TG2000057009) and the Chinese National Natural Science Fund (30225019). ",

year = "2003",

month = oct,

day = "9",

doi = "10.1016/S0304-3940(03)00837-1",

language = "English (US)",

volume = "349",

pages = "209--211",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

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TY - JOUR

T1 - Association study between late-onset Alzheimer's disease and the transferrin gene polymorphisms in Chinese

AU - Zhang, Peng

AU - Yang, Ze

AU - Zhang, Chuanfang

AU - Lu, Zeping

AU - Shi, Xiaohong

AU - Zheng, Weidong

AU - Wan, Chunling

AU - Zhang, Duanyang

AU - Zheng, Chenguang

AU - Li, Shu

AU - Jin, Feng

AU - Wang, Li

N1 - Funding Information: This work was supported by the National “863” Program (2002AA223031), the National “973” Program (TG2000057009) and the Chinese National Natural Science Fund (30225019).

PY - 2003/10/9

Y1 - 2003/10/9

N2 - To investigate the possible involvement of the transferrin (TF) gene polymorphism in the manifestation of Alzheimer's disease (AD), we analyzed the TF and apolipoprotein E (APOE) genotypes of 67 sporadic late-onset AD patients and 131 normal elderly controls in the Chinese population. Our data showed that the TF C1 homozygosity carriers had an increased risk of AD in subjects ≥75 years of age, showing that homozygosity for the TF C1 allele was associated with an approximately three-fold increased risk (OR=3.57, 95% CI, 1.24-10.27, P=0.014). No synergic effects were found between the APOE ε4 allele and TF gene polymorphisms.

AB - To investigate the possible involvement of the transferrin (TF) gene polymorphism in the manifestation of Alzheimer's disease (AD), we analyzed the TF and apolipoprotein E (APOE) genotypes of 67 sporadic late-onset AD patients and 131 normal elderly controls in the Chinese population. Our data showed that the TF C1 homozygosity carriers had an increased risk of AD in subjects ≥75 years of age, showing that homozygosity for the TF C1 allele was associated with an approximately three-fold increased risk (OR=3.57, 95% CI, 1.24-10.27, P=0.014). No synergic effects were found between the APOE ε4 allele and TF gene polymorphisms.

KW - Alzheimer's disease

KW - Apolipoprotein E

KW - Chinese

KW - Gene polymorphisms

KW - Transferrin

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U2 - 10.1016/S0304-3940(03)00837-1

DO - 10.1016/S0304-3940(03)00837-1

M3 - Article

C2 - 12951205

AN - SCOPUS:0142091430

SN - 0304-3940

VL - 349

SP - 209

EP - 211

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 3

ER -

Association study between late-onset Alzheimer's disease and the transferrin gene polymorphisms in Chinese

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ASJC Scopus subject areas

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