TY - JOUR
T1 - Association of Paroxysmal Nocturnal Hemoglobinuria with Erythroleukemia
AU - Carmel, Ralph
AU - Coltman, Charles A.
AU - Yatteau, Ronald F.
AU - Costanzi, John J.
PY - 1970/12/10
Y1 - 1970/12/10
N2 - PAROXYSMAL nocturnal hemoglobinuria (PNH)1 and erythroleukemia2 are both characterized by acquired abnormalities of red blood cells and also feature involvement of other hematopoietic cell lines. With recent reports of PNH terminating in myelogenous leukemia,3 4 5 Dameshek6 hypothesized that PNH may fit into the category of myeloproliferative diseases and, indeed, be a variant of erythroleukemia. This report describes the concomitant occurrence of PNH and erythroleukemia. Such an association is a logical link in the progression of PNH to acute leukemia. Case Report L.G., a 32-year-old man, was transferred to Wilford Hall USAF Medical Center in July, 1969, with the diagnosis of PNH.
AB - PAROXYSMAL nocturnal hemoglobinuria (PNH)1 and erythroleukemia2 are both characterized by acquired abnormalities of red blood cells and also feature involvement of other hematopoietic cell lines. With recent reports of PNH terminating in myelogenous leukemia,3 4 5 Dameshek6 hypothesized that PNH may fit into the category of myeloproliferative diseases and, indeed, be a variant of erythroleukemia. This report describes the concomitant occurrence of PNH and erythroleukemia. Such an association is a logical link in the progression of PNH to acute leukemia. Case Report L.G., a 32-year-old man, was transferred to Wilford Hall USAF Medical Center in July, 1969, with the diagnosis of PNH.
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U2 - 10.1056/NEJM197012102832408
DO - 10.1056/NEJM197012102832408
M3 - Article
C2 - 5273674
AN - SCOPUS:0014940738
SN - 0028-4793
VL - 283
SP - 1329
EP - 1331
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 24
ER -