Association of healthy dietary patterns and cardiorespiratory fitness in the community

Michael Y. Mi, Priya Gajjar, Maura E. Walker, Patricia Miller, Vanessa Xanthakis, Venkatesh L. Murthy, Martin G. Larson, Ramachandran S. Vasan, Ravi V. Shah, Gregory D. Lewis, Matthew Nayor

Producción científica: Articlerevisión exhaustiva

1 Cita (Scopus)

Resumen

Aims To evaluate the associations of dietary indices and quantitative cardiorespiratory fitness (CRF) measures in a large, community-based sample harnessing metabolomic profiling to interrogate shared biology. Methods Framingham Heart Study (FHS) participants underwent maximum effort cardiopulmonary exercise tests for CRF quantifi- and results cation (via peak VO2) and completed semi-quantitative food frequency questionnaires. Dietary quality was assessed by the Alternative Healthy Eating Index (AHEI) and Mediterranean-style Diet Score (MDS), and fasting blood concentrations of 201 metabolites were quantified. In 2380 FHS participants (54 ± 9 years, 54% female, body mass index 28 ± 5 kg/m2), 1 SD higher AHEI and MDS were associated with 5.2% (1.2 mL/kg/min, 95% CI 4.3–6.0%, P < 0.0001) and 4.5% (1.0 mL/kg/min, 95% CI 3.6–5.3%, P < 0.0001) greater peak VO2 in linear models adjusted for age, sex, total daily energy intake, cardiovascular risk factors, and physical activity. In participants with metabolite profiling (N = 1154), 24 metabolites were concordantly associated with both dietary indices and peak VO2 in multivariable-adjusted linear models (FDR < 5%). Metabolites that were associated with lower CRF and poorer dietary quality included C6 and C7 carnitines, C16:0 ceramide, and dimethylguanidino valeric acid, and metabolites that were positively associated with higher CRF and favourable dietary quality included C38:7 phosphatidylcholine plasmalogen and C38:7 and C40:7 phosphatidylethanolamine plasmalogens. Conclusion Higher diet quality is associated with greater CRF cross-sectionally in a middle-aged community-dwelling sample, and metabolites highlight potential shared favourable effects on cardiometabolic health.

Idioma originalEnglish (US)
Páginas (desde-hasta)1450-1461
Número de páginas12
PublicaciónEuropean Journal of Preventive Cardiology
Volumen30
N.º14
DOI
EstadoPublished - oct 1 2023
Publicado de forma externa

ASJC Scopus subject areas

  • Epidemiology
  • Cardiology and Cardiovascular Medicine

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