Association between inflammatory biomarkers in plasma, radiological severity, and duration of exposure in patients with silicosis

Nayara Felicidade Tomaz Braz, Ana Paula Scalia Carneiro, Mateus Ramos Amorim, Fernanda De Oliveira Ferreira, Ana Cristina Rodrigues Lacerda, Aline Silva De Miranda, Mauro Martins Teixeira, Antonio Lucio Teixeira, Vanessa Amaral Mendonça

Producción científica: Articlerevisión exhaustiva

14 Citas (Scopus)

Resumen

OBJECTIVE:: To evaluate the plasma levels of CCL2, CCL3, CCL11, CCL24, tumor necrosis factor alpha, sTNFR1, and sTNFR2 in subjects exposed to silica (SES) with and without silicosis compared with unexposed reference control group, and their associations with the radiological severity and duration of exposure to silica. METHODS:: Fifty-seven SES; 36 with silicosis and 22 subjects in control group, were included in the study. RESULTS:: CCL3, CCL24, sTNFR1, and sTNFR2 were increased in SES and in SES with silicosis than in controls. There were no differences in the levels of CCL2, CCL11, or tumor necrosis factor alpha. The sTNFR2 level was greater in SES with silicosis than in SES without silicosis. There was a positive correlation between sTNFR1 and sTNFR2 and the radiological severity and time of exposure to silica. sTNFR2 was associated with all categories of radiological severity. CONCLUSION:: sTNFR2 is associated with silicosis severity and early exposure to silica.

Idioma originalEnglish (US)
Páginas (desde-hasta)493-497
Número de páginas5
PublicaciónJournal of occupational and environmental medicine
Volumen56
N.º5
DOI
EstadoPublished - may 2014
Publicado de forma externa

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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