Assignment of xeroderma pigmentosum group c (xpc) gene to chromosome 3p25

Randy J. Legerski; Pu Liu; Lei Li; Carolyn A. Peterson; Ying Zhao; Robin J. Leach; Susan L. Naylor; Michael J. Siciliano

doi:10.1006/geno.1994.1256

Assignment of xeroderma pigmentosum group c (xpc) gene to chromosome 3p25

Randy J. Legerski
, Pu Liu
, Lei Li
, Carolyn A. Peterson
, Ying Zhao
, Robin J. Leach
, Susan L. Naylor
, Michael J. Siciliano

Department of Cell Systems & Anatomy

Producción científica: Article › revisión exhaustiva

17 Citas (Scopus)

Resumen

The human gene XPC (formerly designated XPCC), which corrects the repair deficiency of xeroderma pigmentosum (XP) group C cells, was mapped to 3p25. A cDNA probe for Southern blot hybridization and diagnostic PCR analyses of hybrid clone panels informative for human chromosomes in general and portions of chromosome 3 in particular produced the initial results. Fluorescence in situ hybridization utilizing both a yeast artificial chromosome DNA containing the gene and XPC cDNA as probes provided verification and specific regional assignment. A conflicting assignment of XPC to chromosome 5 is discussed in light of inadequacies in the exclusive use of microcell-mediated chromosome transfer for gene mapping.

Idioma original	English (US)
Páginas (desde-hasta)	266-269
Número de páginas	4
Publicación	Genomics
Volumen	21
N.º	1
DOI	https://doi.org/10.1006/geno.1994.1256
Estado	Published - may 1 1994

ASJC Scopus subject areas

Genetics

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10.1006/geno.1994.1256

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title = "Assignment of xeroderma pigmentosum group c (xpc) gene to chromosome 3p25",

abstract = "The human gene XPC (formerly designated XPCC), which corrects the repair deficiency of xeroderma pigmentosum (XP) group C cells, was mapped to 3p25. A cDNA probe for Southern blot hybridization and diagnostic PCR analyses of hybrid clone panels informative for human chromosomes in general and portions of chromosome 3 in particular produced the initial results. Fluorescence in situ hybridization utilizing both a yeast artificial chromosome DNA containing the gene and XPC cDNA as probes provided verification and specific regional assignment. A conflicting assignment of XPC to chromosome 5 is discussed in light of inadequacies in the exclusive use of microcell-mediated chromosome transfer for gene mapping.",

author = "Legerski, \{Randy J.\} and Pu Liu and Lei Li and Peterson, \{Carolyn A.\} and Ying Zhao and Leach, \{Robin J.\} and Naylor, \{Susan L.\} and Siciliano, \{Michael J.\}",

year = "1994",

month = may,

day = "1",

doi = "10.1006/geno.1994.1256",

language = "English (US)",

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T1 - Assignment of xeroderma pigmentosum group c (xpc) gene to chromosome 3p25

AU - Legerski, Randy J.

AU - Liu, Pu

AU - Li, Lei

AU - Peterson, Carolyn A.

AU - Zhao, Ying

AU - Leach, Robin J.

AU - Naylor, Susan L.

AU - Siciliano, Michael J.

PY - 1994/5/1

Y1 - 1994/5/1

N2 - The human gene XPC (formerly designated XPCC), which corrects the repair deficiency of xeroderma pigmentosum (XP) group C cells, was mapped to 3p25. A cDNA probe for Southern blot hybridization and diagnostic PCR analyses of hybrid clone panels informative for human chromosomes in general and portions of chromosome 3 in particular produced the initial results. Fluorescence in situ hybridization utilizing both a yeast artificial chromosome DNA containing the gene and XPC cDNA as probes provided verification and specific regional assignment. A conflicting assignment of XPC to chromosome 5 is discussed in light of inadequacies in the exclusive use of microcell-mediated chromosome transfer for gene mapping.

AB - The human gene XPC (formerly designated XPCC), which corrects the repair deficiency of xeroderma pigmentosum (XP) group C cells, was mapped to 3p25. A cDNA probe for Southern blot hybridization and diagnostic PCR analyses of hybrid clone panels informative for human chromosomes in general and portions of chromosome 3 in particular produced the initial results. Fluorescence in situ hybridization utilizing both a yeast artificial chromosome DNA containing the gene and XPC cDNA as probes provided verification and specific regional assignment. A conflicting assignment of XPC to chromosome 5 is discussed in light of inadequacies in the exclusive use of microcell-mediated chromosome transfer for gene mapping.

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AN - SCOPUS:0028290747

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JO - Genomics

JF - Genomics

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Assignment of xeroderma pigmentosum group c (xpc) gene to chromosome 3p25

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