Assay of fluconazole by high-performance liquid chromatography with a mixed-phase column

J. E. Wallace, S. C. Harris, J. Gallegos, G. Foulds, T. J.H. Chen, M. G. Rinaldi

Resultado de la investigación: Articlerevisión exhaustiva

37 Citas (Scopus)

Resumen

A mixed-phase liquid chromatographic column was used to assay fluconazole in plasma, serum, and cerebrospinal fluid. The assay was linear from 0.2 to 20 μg/ml, with an average coefficient of variation of less than 5%. The partitioning of the drug between serum and cerebrospinal fluid was determined for 34 patients. The method was demonstrated to be suitable for both pharmacokinetic studies and monitoring of patients receiving treatment with this antifungal agent.

Idioma originalEnglish (US)
Páginas (desde-hasta)603-606
Número de páginas4
PublicaciónAntimicrobial agents and chemotherapy
Volumen36
N.º3
DOI
EstadoPublished - 1992
Publicado de forma externa

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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