Aquatic light/dark plus maze novel environment for assessing anxious versus exploratory behavior in zebrafish (Danio rerio) and other small teleost fish

Producción científica: Chapter

11 Citas (Scopus)

Resumen

Initial introduction into novel environments produces in zebrafish behaviors consistent with predator evasion, fear, and/or anxiety. This protocol is for a light/dark plus maze novel environment test utilizing two elements of those behavioral responses, thigmotaxis and light avoidance, to assess "anxiety states" in zebrafish. The test is based upon the rodent elevated plus maze and is scored similarly, except for fish white arms replace opened arms, and black arms parallel closed arms. Several pharmaceuticals that reduce anxiety levels in patients and increase open arm exploration by rodents in the elevated plus maze also increase zebrafish entries into and time spent in white arms of the maze.

Idioma originalEnglish (US)
Título de la publicación alojadaZebrafish Neurobehavioral Protocols
EditoresAllan Kalueff, Jonathan Cachat
Páginas99-108
Número de páginas10
DOI
EstadoPublished - 2011

Serie de la publicación

NombreNeuromethods
Volumen51
ISSN (versión impresa)0893-2336
ISSN (versión digital)1940-6045

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • General Pharmacology, Toxicology and Pharmaceutics
  • General Biochemistry, Genetics and Molecular Biology
  • General Neuroscience

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