APOBEC3F determinants of HIV-1 Vif sensitivity

Allison M. Land; Nadine M. Shaban; Leah Evans; Judd F. Hultquist; John S. Albin; Reuben S. Harris

doi:10.1128/JVI.02362-14

APOBEC3F determinants of HIV-1 Vif sensitivity

Allison M. Land
, Nadine M. Shaban
, Leah Evans
, Judd F. Hultquist
, John S. Albin
, Reuben S. Harris

Producción científica: Article › revisión exhaustiva

12 Citas (Scopus)

Resumen

HIV-1 Vif counteracts restrictive APOBEC3 proteins by targeting them for proteasomal degradation. To determine the regions mediating sensitivity to Vif, we compared human APOBEC3F, which is HIV-1 Vif sensitive, with rhesus APOBEC3F, which is HIV-1 Vif resistant. Rhesus-human APOBEC3F chimeras and amino acid substitution mutants were tested for sensitivity to HIV-1 Vif. This approach identified the α3 and α4 helices of human APOBEC3F as important determinants of the interaction with HIV-1 Vif.

Idioma original	English (US)
Páginas (desde-hasta)	12923-12927
Número de páginas	5
Publicación	Journal of virology
Volumen	88
N.º	21
DOI	https://doi.org/10.1128/JVI.02362-14
Estado	Published - 2014
Publicado de forma externa	Sí

ASJC Scopus subject areas

Insect Science
Virology
Microbiology
Immunology

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10.1128/JVI.02362-14

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title = "APOBEC3F determinants of HIV-1 Vif sensitivity",

abstract = "HIV-1 Vif counteracts restrictive APOBEC3 proteins by targeting them for proteasomal degradation. To determine the regions mediating sensitivity to Vif, we compared human APOBEC3F, which is HIV-1 Vif sensitive, with rhesus APOBEC3F, which is HIV-1 Vif resistant. Rhesus-human APOBEC3F chimeras and amino acid substitution mutants were tested for sensitivity to HIV-1 Vif. This approach identified the α3 and α4 helices of human APOBEC3F as important determinants of the interaction with HIV-1 Vif.",

author = "Land, \{Allison M.\} and Shaban, \{Nadine M.\} and Leah Evans and Hultquist, \{Judd F.\} and Albin, \{John S.\} and Harris, \{Reuben S.\}",

note = "Publisher Copyright: {\textcopyright} 2014, American Society for Microbiology.",

year = "2014",

doi = "10.1128/JVI.02362-14",

language = "English (US)",

volume = "88",

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T1 - APOBEC3F determinants of HIV-1 Vif sensitivity

AU - Land, Allison M.

AU - Shaban, Nadine M.

AU - Evans, Leah

AU - Hultquist, Judd F.

AU - Albin, John S.

AU - Harris, Reuben S.

PY - 2014

Y1 - 2014

N2 - HIV-1 Vif counteracts restrictive APOBEC3 proteins by targeting them for proteasomal degradation. To determine the regions mediating sensitivity to Vif, we compared human APOBEC3F, which is HIV-1 Vif sensitive, with rhesus APOBEC3F, which is HIV-1 Vif resistant. Rhesus-human APOBEC3F chimeras and amino acid substitution mutants were tested for sensitivity to HIV-1 Vif. This approach identified the α3 and α4 helices of human APOBEC3F as important determinants of the interaction with HIV-1 Vif.

AB - HIV-1 Vif counteracts restrictive APOBEC3 proteins by targeting them for proteasomal degradation. To determine the regions mediating sensitivity to Vif, we compared human APOBEC3F, which is HIV-1 Vif sensitive, with rhesus APOBEC3F, which is HIV-1 Vif resistant. Rhesus-human APOBEC3F chimeras and amino acid substitution mutants were tested for sensitivity to HIV-1 Vif. This approach identified the α3 and α4 helices of human APOBEC3F as important determinants of the interaction with HIV-1 Vif.

UR - https://www.scopus.com/pages/publications/84907992902

UR - https://www.scopus.com/pages/publications/84907992902#tab=citedBy

U2 - 10.1128/JVI.02362-14

DO - 10.1128/JVI.02362-14

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AN - SCOPUS:84907992902

SN - 0022-538X

VL - 88

SP - 12923

EP - 12927

JO - Journal of virology

JF - Journal of virology

IS - 21

ER -

APOBEC3F determinants of HIV-1 Vif sensitivity

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