Apego no resuelto desorganizado ajustado a un Factor de Psicopatología General asociado con conectividad funcional atípica de la amígdala en estado de reposo

Marie José van Hoof, Madelon M.E. Riem, Amy S. Garrett, Nic J.A. van der Wee, Marinus H. van IJzendoorn, Robert R.J.M. Vermeiren

Resultado de la investigación: Articlerevisión exhaustiva

8 Citas (Scopus)

Resumen

Background: Recent research has identified a general psychopathology factor (GPF), which explains overlap in presentation of psychopathological symptoms. Unresolved–disorganized attachment (Ud) is another transdiagnostic risk factor that may be relevant to explain differences in patient characteristics within diagnostic classifications. Objective: In the current study, we examined unique relations of resting-state functional connectivity (RSFC) with Ud and GPF. Method: RSFC data were collected from a mixed group of adolescents (N = 74) with and without psychiatric disorder, as part of the Emotional Pathways’ Imaging Study in Clinical Adolescents (EPISCA) study. Ud was measured using the Adult Attachment Interview (AAI). Associations between Ud, GPF, and RSFC of the amygdala and dorsal anterior cingulate cortex (dACC) and with amygdala–medial frontal connectivity were examined. Results: Ud was positively associated with greater functional connectivity between the left amygdala and the left lateral occipital cortex, precuneus, and superior parietal lobule. Furthermore, Ud was negatively associated with left amygdala–medial frontal cortex connectivity. GPF was not significantly associated with dACC or amygdala connectivity. Conclusions: Atypical amygdala connectivity may reflect a vulnerability factor rather than a biomarker of psychopathology. The unique association of Ud and amygdala RSFC, adjusted for a GPF, across participants with and without various classifications of psychopathology illustrates that dimensional approaches based on the AAI may complement psychiatric classifications in clinical research and practice.

Título traducido de la contribuciónUnresolved–disorganized attachment adjusted for a general psychopathology factor associated with atypical amygdala resting-state functional connectivity
Idioma originalSpanish
Número de artículo1583525
PublicaciónEuropean Journal of Psychotraumatology
Volumen10
N.º1
DOI
EstadoPublished - ene. 1 2019

ASJC Scopus subject areas

  • Psychiatry and Mental health

Huella

Profundice en los temas de investigación de 'Apego no resuelto desorganizado ajustado a un Factor de Psicopatología General asociado con conectividad funcional atípica de la amígdala en estado de reposo'. En conjunto forman una huella única.

Citar esto